A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1 (Q73958442)

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8 November 2019

title

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1 (English)

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8 November 2019

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1

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8 November 2019

William J. Ray

7

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8 November 2019

author name string

E H Schroeter

2

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8 November 2019

M T Saxena

3

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8 November 2019

A Griesemer

4

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8 November 2019

X Tian

5

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8 November 2019

D J Pan

6

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8 November 2019

R Kopan

8

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8 November 2019

publication date

1 February 2000

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8 November 2019

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8 November 2019

volume

5

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8 November 2019

issue

2

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8 November 2019

page(s)

197-206

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Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch

8 November 2019

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Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

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Roles for proteolysis and trafficking in notch maturation and signal transduction

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Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

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Notch signaling in vertebrate development and disease

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Alzheimer's disease. In search of gamma-secretase.

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Signalling downstream of activated mammalian Notch

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7 January 2021

Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

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7 January 2021

Transforming the cell surface through proteolysis

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7 January 2021

Notch/LIN-12 signaling: transduction by regulated protein slicing

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7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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7 January 2021

Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

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Notch signalling and the control of cell fate choices in vertebrates.

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

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7 January 2021

Jagged: a mammalian ligand that activates Notch1

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7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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7 January 2021

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

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7 January 2021

Regulation of amyloid precursor protein cleavage.

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7 January 2021

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

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7 January 2021

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

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7 January 2021

An essential role for ectodomain shedding in mammalian development

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7 January 2021

Processing of the notch ligand delta by the metalloprotease Kuzbanian

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7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

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7 January 2021

Evidence for a physical interaction between presenilin and Notch

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7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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7 January 2021

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.

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7 January 2021

Xenopus embryos regulate the nuclear localization of XMyoD

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7 January 2021

The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface

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7 January 2021

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

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7 January 2021

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7 January 2021

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7 January 2021

Role for ADAM-family proteinases as membrane protein secretases.

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7 January 2021

The ins and outs of notch signaling

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882062%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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