Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody (Q74148034)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12023970%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12023970%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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Sabina Janciauskiene

1

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9 November 2019

Ruta Dominaitiene

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12023970%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Nils H Sternby

3

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9 November 2019

Eva Piitulainen

4

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9 November 2019

Sten Eriksson

5

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9 November 2019

language of work or name

English

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publication date

22 May 2002

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Journal of Biological Chemistry

9 November 2019

published in

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9 November 2019

volume

277

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9 November 2019

page(s)

26540-26546

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9 November 2019

issue

29

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describes a project that uses

9 November 2019

1 reference

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Serpins and other covalent protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Immunological Detection of Conformational Neoepitopes Associated with the Serpin Activity of Plasminogen Activator Inhibitor Type-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Production of monoclonal antibodies against inactivated alpha 1-antitrypsin. Cross-reactivity with complexed alpha 1-antitrypsin and application in an assay to determine inactivated and complexed alpha 1-antitrypsin in biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Alpha1-antitrypsin deficiency--a model for conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Alpha 1-antitrypsin deficiency. A conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Molecular biology and respiratory disease. 7. The alpha 1 antitrypsin gene and chronic lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Loop-sheet polymerization: the mechanism of alpha1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Monoclonal antibody specific for the mutant PiZ alpha 1-antitrypsin and its application in an ELISA procedure for identification of PiZ gene carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A beta-sheet of the inhibitor during trapping of target proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Significance of secondary structure predictions on the reactive center loop region of serpins: a model for the folding of serpins into a metastable state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Effects of noninhibitory alpha-1-antitrypsin on primary human monocyte activation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Preparation and characterization of latent alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Chronic 'cryptogenic' liver disease and malignant hepatoma in intermediate alpha 1-antitrypsin deficiency identified by a Pi Z-specific monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Strong link between the alpha 1-antitrypsin PiZ allele and Wegener's granulomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Serine protease inhibitors in patients with chronic viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Identification of PiZ gene products in liver tissue by a monoclonal antibody specific for the Z mutant of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Distribution of the native strain in human alpha 1-antitrypsin and its association with protease inhibitor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Structural aspects of serpin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Type-1 inhibitor of plasminogen activators. Distinction between latent, activated and reactive centre-cleaved forms with thermal stability and monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Short-course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Alpha-1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

A 30-year perspective on alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Liver injury in alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Immunochemical and functional properties of biliary alpha-1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Endothelial serpins--protectors of the vasculature?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203832200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203832200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12023970%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference