Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes (Q74425554)

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10 November 2019

title

Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes (English)

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10 November 2019

author name string

L H Cohen

1

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10 November 2019

R E van Leeuwen

2

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10 November 2019

G C van Thiel

3

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10 November 2019

J F van Pelt

4

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10 November 2019

S H Yap

5

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10 November 2019

publication date

1 December 2000

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Biopharmaceutics and Drug Disposition

10 November 2019

published in

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10 November 2019

volume

21

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10 November 2019

page(s)

353-364

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10 November 2019

issue

9

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CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

10 November 2019

cites work

1 reference

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

21 January 2018

1 reference

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin

21 January 2018

1 reference

Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors

21 January 2018

1 reference

Cerivastatin: pharmacology of a novel synthetic and highly active HMG-CoA reductase inhibitor

21 January 2018

1 reference

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

21 January 2018

1 reference

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

21 January 2018

1 reference

Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types

21 January 2018

1 reference

Vastatins have a distinct effect on sterol synthesis and progesterone secretion in human granulosa cells in vitro

21 January 2018

1 reference

Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle

21 January 2018

1 reference

Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes

21 January 2018

1 reference

In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors

21 January 2018

1 reference

Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity.

21 January 2018

1 reference

Retinoids stimulate ApoA-I synthesis by induction of gene transcription in primary hepatocyte cultures from cynomolgus monkey (Macaca fascicularis)

21 January 2018

1 reference

The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system

21 January 2018

1 reference

Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

21 January 2018

1 reference

Cryopreservation of adult human hepatocytes. The influence of deep freezing storage on the viability, cell seeding, survival, fine structures and albumin synthesis in primary cultures.

21 January 2018

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Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

21 January 2018

1 reference

Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

21 January 2018

1 reference

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

21 January 2018

1 reference

Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.

21 January 2018

1 reference

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

21 January 2018

1 reference

The interaction of diltiazem with lovastatin and pravastatin

21 January 2018

1 reference

Effect of itraconazole on the pharmacokinetics of atorvastatin

21 January 2018

1 reference

Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations

21 January 2018

1 reference

Rhabdomyolysis due to interaction of simvastatin with mibefradil

21 January 2018

1 reference

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

21 January 2018

1 reference

Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

21 January 2018

1 reference

Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine

21 January 2018

1 reference

The effects of fluvastatin, a CYP2C9 inhibitor, on losartan pharmacokinetics in healthy volunteers

21 January 2018

1 reference

Effect of fluconazole on plasma fluvastatin and pravastatin concentrations

21 January 2018

1 reference

'Fire and forget?' - pharmacological considerations in coronary care

21 January 2018

1 reference

[Drug interactions with the cytochrome P-450 system]

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BDD.249

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11523064%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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