Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes (Q74539246)

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11 November 2019

title

Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes (English)

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11 November 2019

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quantitative structure-activity relationship

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D F Lewis

1

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11 November 2019

B G Lake

series ordinal

2

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11 November 2019

publication date

1 January 1998

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11 November 2019

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11 November 2019

volume

125

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11 November 2019

issue

1

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11 November 2019

page(s)

31-44

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Omeprazole drug interaction studies

11 November 2019

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CYP1A1: friend or foe?

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Assays of omeprazole metabolism as a substrate probe for human CYP isoforms

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The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.

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Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

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Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

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Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole

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Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity

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Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line

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Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

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Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

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Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals

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Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

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Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

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7 January 2021

Omeprazole, cytochrome P450, and chemical carcinogenesis

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7 January 2021

Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats

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7 January 2021

The binding to oxidised cytochromes P-450 and inhibition of mixed-function oxidases by aryl-substituted benzimidazoles and related compounds

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Interaction of omeprazole with DNA in rat tissues

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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7 January 2021

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Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test

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Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

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7 January 2021

The pharmacology of the gastric acid pump: the H+,K+ ATPase

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7 January 2021

Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects

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In vivo and in vitro measurement of CYP2C19 activity

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7 January 2021

The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9585098%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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