Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins (Q40700838)

22 September 2017

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title

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins (English)

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22 September 2017

Gonzalez FJ

1

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PubMed ID

8082563

22 September 2017

Gelboin HV

series ordinal

2

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PubMed ID

8082563

22 September 2017

language of work or name

English

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publication date

1 January 1994

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22 September 2017

Drug Metabolism Reviews

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22 September 2017

26

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22 September 2017

1-2

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22 September 2017

165-183

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Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.

22 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of CYP1A1 and CYP1A2 genes in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Effect of smoking on caffeine clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Molecular genetics of the debrisoquin-sparteine polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The human hepatic cytochromes P450 involved in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

The metabolism of 1-nitropyrene by human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Pharmacokinetics of nifedipine slow release tablet in Mexican subjects: further evidence for an oxidation polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Characterization of human microsomal cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029789

10.3109/03602539409029789

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

8082563