Nuclear receptor subfamily 5 group A member 1 (Q7611614)

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mammalian protein found in Homo sapiens

adrenal 4 binding protein
nuclear receptor AdBP4
steroidogenic factor 1
steroidogenic factor-1
STF-1
steroid hormone receptor Ad4BP
steroidogenic factor 1 nuclear receptor
Adrenal 4-binding protein
fushi tarazu factor homolog 1
NR5A1

Language	Label	Description	Also known as
English	Nuclear receptor subfamily 5 group A member 1	mammalian protein found in Homo sapiens	adrenal 4 binding protein nuclear receptor AdBP4 steroidogenic factor 1 steroidogenic factor-1 STF-1 steroid hormone receptor Ad4BP steroidogenic factor 1 nuclear receptor Adrenal 4-binding protein fushi tarazu factor homolog 1 NR5A1

Statements

1 reference

13 November 2019

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13285

Zinc finger, NHR/GATA-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13285

Nuclear hormone receptor family 5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13285

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein NR5A1 PDB 1ymt.png
854 × 792; 390 KB

1 reference

imported from Wikimedia project

Spanish Wikipedia

Wikimedia import URL

https://es.wikipedia.org/w/index.php?title=NR5A1&oldid=119693649

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

9 references

8 April 2019

The role of human MBF1 as a transcriptional coactivator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Loss-of-function mutation in GATA4 causes anomalies of human testicular development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

double-stranded DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

determination method

1 reference

8 April 2019

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

10 September 2018

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

steroid hormone receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

phospholipid binding

determination method

1 reference

8 April 2019

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

The role of human MBF1 as a transcriptional coactivator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

chromatin binding

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

nuclear receptor activity

determination method

2 references

sequence-specific DNA binding

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

transcription cis-regulatory region binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

nuclear receptor activity

determination method

3 references

8 April 2019

Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

RNA polymerase II transcription regulator complex

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

The role of human MBF1 as a transcriptional coactivator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

biological process

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

regulation of steroid biosynthetic process

determination method

1 reference

8 April 2019

The role of human MBF1 as a transcriptional coactivator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

hormone metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

reproductive process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

primary sex determination

determination method

1 reference

8 April 2019

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

multicellular organism aging

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

maintenance of protein location in nucleus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

adrenal gland development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

transcription, DNA-templated

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

cell-cell signaling

determination method

1 reference

24 April 2018

A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

negative regulation of female gonad development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

intracellular receptor signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

16 July 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

16 July 2018

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

16 July 2018

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13285&geneProductId=UniProtKB:Q13285

determination method

sex-determination system

determination method

5 references

8 April 2019

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

The novel p.Cys65Tyr mutation in NR5A1 gene in three 46,XY siblings with normal testosterone levels and their mother with primary ovarian insufficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

male gonad development

determination method

4 references

8 April 2019

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

positive regulation of gene expression

determination method

calcineurin-mediated signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

response to gonadotropin-releasing hormone

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

male sex determination

determination method

1 reference

8 April 2019

A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

positive regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13285

determination method

Gene Atlas image

PBB GE NR5A1 210333 at fs.png
732 × 530; 11 KB

0 references

nuclear hormone receptor-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13285

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13285

Identifiers

MeSH descriptor ID

subject named as

Steroidogenic Factor 1

0 references

D12.776.826.925

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362690

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362690

ENSP00000362689

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362689

ENSP00000393245

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393245

ENSP00000483309

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483309

Google Knowledge Graph ID

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(1 entry)

eswiki NR5A1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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