Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (Q77896965)

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9 December 2019

title

Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (English)

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9 December 2019

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7

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9 December 2019

author name string

D T Minnick

1

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9 December 2019

K Bebenek

2

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9 December 2019

W P Osheroff

3

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9 December 2019

R M Turner

4

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9 December 2019

M Astatke

5

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9 December 2019

L Liu

6

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9 December 2019

C M Joyce

8

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9 December 2019

language of work or name

English

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publication date

1 January 1999

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Journal of Biological Chemistry

9 December 2019

published in

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9 December 2019

volume

274

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9 December 2019

issue

5

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9 December 2019

page(s)

3067-3075

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Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates

9 December 2019

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Structural and mechanistic relationships between nucleic acid polymerases

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Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes.

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Function and structure relationships in DNA polymerases

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Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).

21 January 2018

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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Structure of Taq polymerase with DNA at the polymerase active site

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

21 January 2018

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Structure of DNA polymerase I Klenow fragment bound to duplex DNA

21 January 2018

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Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

21 January 2018

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A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

21 January 2018

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Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain

21 January 2018

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A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity.

21 January 2018

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Analyzing fidelity of DNA polymerases.

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Purification of Escherichia coli DNA polymerase I and Klenow fragment.

21 January 2018

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How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides

21 January 2018

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Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.

21 January 2018

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Exonucleolytic proofreading during replication of repetitive DNA

21 January 2018

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Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

21 January 2018

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Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.

21 January 2018

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A minor groove binding track in reverse transcriptase

21 January 2018

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A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides

21 January 2018

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Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity

21 January 2018

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On molecular mechanisms of nucleic acid synthesis. Fidelity aspects: 2. Contribution of protein-nucleotide recognition

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Sequence-specific recognition of double helical nucleic acids by proteins

21 January 2018

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