Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone (Q78732204)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

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title

Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

0 references

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Paul Workman

1

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16 December 2019

publication date

1 January 2002

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Cancer Detection and Prevention

16 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

26

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16 December 2019

issue

6

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16 December 2019

page(s)

405-410

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Discovering novel chemotherapeutic drugs for the third millennium

16 December 2019

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Clinical and biological significance of HSP89 alpha in human breast cancer

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Over-expression of heat shock proteins in carcinogenic endometrium

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

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Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507224%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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