Deconstructing fragment-based inhibitor discovery (Q79314147)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

Deconstructing fragment-based inhibitor discovery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

author name string

Kerim Babaoglu

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Brian K Shoichet

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

publication date

29 October 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

page(s)

720-723

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17072304%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio831

21 December 2019

exact match

0 references

cites work

Fragment-Based Drug Discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Tethering: fragment-based drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Fragment-based lead discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Ligand efficiency: a useful metric for lead selection

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

New lead generation strategies for protein kinase inhibitors - fragment based screening approaches

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Fragment-based lead discovery using X-ray crystallography.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Utilization of NMR-derived fragment leads in drug design

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Structure-based approach for binding site identification on AmpC beta-lactamase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

The additivity of substrate fragments in enzyme-ligand binding

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

1 reference

7 January 2021

Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Catalytic proficiency: the unusual case of OMP decarboxylase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

From The Cover: Automated protein crystal structure determination using ELVES

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021

Coot: model-building tools for molecular graphics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO831

7 January 2021