The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA (Q80184251)

From Wikidata

Jump to navigation Jump to search

scientific article published on 28 August 2006

Language	Label	Description	Also known as
English	The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA	scientific article published on 28 August 2006

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA gyrase (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Staphylococcus aureus

1 reference

based on heuristic

inferred from title

methicillin-resistant Staphylococcus aureus

1 reference

based on heuristic

inferred from title

author name string

Sachin S Bhagwat

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Lakshmi A Mundkur

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Shrikant V Gupte

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Mahesh V Patel

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Habil F Khorakiwala

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

28 August 2006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

50

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

3568-3579

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staphylococcus aureus mutants selected by BMS-284756.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual activity of fluoroquinolones against Streptococcus pneumoniae: the facts behind the claims

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility change to antibiotics of Staphylococcus aureus strains isolated from skin infections between July 1994 and November 2000.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoroquinolones: structure and target sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro potency of moxifloxacin, clinafloxacin and sitafloxacin against 248 genetically defined clinical isolates of Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of and resistance to moxifloxacin in Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selection of moxifloxacin-resistant Staphylococcus aureus compared with five other fluoroquinolones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mutant selection window and antimicrobial resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolone Resistance Due to Reduced Target Enzyme Expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of minimal inhibitory and mutant prevention drug concentrations of 4 fluoroquinolones against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of the new quinolone WCK 771 against staphylococci

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of Staphylococcus aureus, isolated from skin infections in 1994, to 19 antimicrobial agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of grlA and gyrA mutations in 344 Staphylococcus aureus strains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of gyrA, gyrB, grlA and grlB mutations in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activities of 13 fluoroquinolones against Staphylococcus aureus isolates with characterized mutations in gyrA, gyrB, grlA, and norA and against wild-type isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antistaphylococcal activity of WCK 771, a tricyclic fluoroquinolone, in animal infection models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diversity of quinolone resistance in genetically related clinical isolates of Staphylococcus aureus and susceptibility to newer quinolones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00641-06

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16940059%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q80184251&oldid=1683346063"