Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways (Q80675965)

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2 January 2020

title

Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways (English)

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2 January 2020

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Leander Gaul

1

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2 January 2020

Sonja Mandl-Weber

2

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2 January 2020

Philipp Baumann

3

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2 January 2020

Bertold Emmerich

4

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2 January 2020

Ralf Schmidmaier

5

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2 January 2020

publication date

25 July 2007

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Journal of Cancer Research and Clinical Oncology

2 January 2020

published in

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2 January 2020

volume

134

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2 January 2020

issue

2

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2 January 2020

page(s)

245-253

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Rapid destruction of human Cdc25A in response to DNA damage

2 January 2020

cites work

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12 December 2020

Cell cycle checkpoint signaling through the ATM and ATR kinases

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12 December 2020

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

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12 December 2020

Bendamustine as salvage treatment in patients with advanced progressive breast cancer: a phase II study

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12 December 2020

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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12 December 2020

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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12 December 2020

Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: results of a randomized controlled trial

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12 December 2020

Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53.

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12 December 2020

Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy.

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12 December 2020

Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines.

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12 December 2020

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

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12 December 2020

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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12 December 2020

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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12 December 2020

Delayed cyclin B1 expression during the G2 arrest following DNA damage

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12 December 2020

Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway

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12 December 2020

High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma

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Cytotoxic efficacy of bendamustine in human leukemia and breast cancer cell lines

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Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.

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12 December 2020

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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12 December 2020

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

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12 December 2020

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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12 December 2020

The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy

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12 December 2020

Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

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12 December 2020

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

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12 December 2020

Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and predniso

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12 December 2020

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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12 December 2020

A role for ATR in the DNA damage-induced phosphorylation of p53

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12 December 2020

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

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12 December 2020

Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

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12 December 2020

Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialists' Collaborative Group

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12 December 2020

Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacologic implications

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12 December 2020

Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19).

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12 December 2020

Universal control mechanism regulating onset of M-phase

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12 December 2020

Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint

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12 December 2020

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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12 December 2020

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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12 December 2020

Bendamustine prolongs progression-free survival in metastatic breast cancer (MBC): a phase III prospective, randomized, multicenter trial of bendamustine hydrochloride, methotrexate and 5-fluorouracil (BMF) versus cyclophosphamide, methotrexate and

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12 December 2020

Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma

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12 December 2020

A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome

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12 December 2020

Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas.

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12 December 2020

Regression of brain metastases from breast carcinoma after chemotherapy with bendamustine

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12 December 2020

The enigmatic effects of caffeine in cell cycle and cancer

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12 December 2020

Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia

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12 December 2020

Activation of ATM and phosphorylation of p53 by heat shock

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12 December 2020

Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

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12 December 2020

CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.

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12 December 2020

10.1007/S00432-007-0278-X

Identifiers

DOI

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2 January 2020

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