Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study (Q82385512)

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scientific article published on 01 December 2011

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English	Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study	scientific article published on 01 December 2011

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16 January 2020

Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study (English)

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16 January 2020

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E Cadirci

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Z Halici

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F Odabasoglu

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A Albayrak

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E Karakus

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I Ferah

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B Unal

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1 December 2011

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Clinical and Experimental Immunology

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166

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16 January 2020

374-384

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16 January 2020

PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo

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https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Pathogenetic mechanisms of septic shock

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12 December 2020

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Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Oxidative stress in skeletal muscle during sepsis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Effect of prostaglandin E1 (PGE1) and sildenafil on serotonin metabolism and some oxidative damage markers in rat prostate gland and brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Plasma lipid peroxides and antioxidants in human septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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A simple method for clinical assay of superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Cytokine modulation in sepsis and septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Free radicals and antioxidants in sepsis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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The role of free radicals in sepsis development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Role of oxygen free radicals in shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Acute renal failure and sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Effect of sildenafil in renal ischemia/reperfusion injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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The new vitamin E derivative, ETS-GS, protects against cecal ligation and puncture-induced systemic inflammation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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The effect of sildenafil on cisplatin nephrotoxicity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Correlation of plasma and tissue oxidative stresses in intra-abdominal sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Experimental therapeutic strategies for severe sepsis: mediators and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Pathological aspects of apoptosis in severe sepsis and shock?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

1 reference

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12 December 2020

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BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Reactive oxygen species in acute lung injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Treatment of pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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The pathophysiology and treatment of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Prominent expression of phosphodiesterase 5 in striated muscle of the rat urethra and levator ani.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Statins: panacea for sepsis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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The pathophysiology of septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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The effect of preoperative internal and external biliary drainage on mortality of jaundiced rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Time course of oxidative stress during open-heart surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Definition of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Sildenafil improves alveolar growth and pulmonary hypertension in hyperoxia-induced lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Lipid peroxide formation and membrane damage in endotoxin-poisoned mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine serum level during severe sepsis in human IL-6 as a marker of severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of polymicrobial sepsis with diabetes mellitus on kidney tissues in ovariectomized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trauma: the role of the innate immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

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Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does N-acetyl-L-cysteine influence cytokine response during early human septic shock?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, transcription factors, and intestinal inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22059996

12 December 2020

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Identifiers

10.1111/J.1365-2249.2011.04483.X

1 reference

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16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22059996%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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