The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis (Q83185411)

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19 January 2020

title

The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis (English)

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19 January 2020

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19 January 2020

author name string

Kiran Assi

1

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19 January 2020

Rex Pillai

2

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19 January 2020

David Owen

4

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19 January 2020

Baljinder Salh

5

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19 January 2020

publication date

1 May 2006

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19 January 2020

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19 January 2020

volume

118

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19 January 2020

issue

1

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19 January 2020

page(s)

112-121

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

19 January 2020

cites work

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12 December 2020

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

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12 December 2020

Evolving treatment strategies for inflammatory bowel disease

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12 December 2020

Signal transduction by the JNK group of MAP kinases

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PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells.

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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12 December 2020

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

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12 December 2020

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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12 December 2020

Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

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12 December 2020

Nods: a family of cytosolic proteins that regulate the host response to pathogens

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12 December 2020

The immunology of mucosal models of inflammation

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12 December 2020

Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis

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12 December 2020

p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

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12 December 2020

Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.

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12 December 2020

Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis

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12 December 2020

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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12 December 2020

c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.

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12 December 2020

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

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JNK and p38 MAP kinases in CD4+ and CD8+ T cells

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12 December 2020

Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice

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Curcumin attenuates DNB-induced murine colitis.

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Targeting JNK for therapeutic benefit: from junk to gold?

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TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

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Recognition of microbial infection by Toll-like receptors

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Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

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The safety profile of infliximab in patients with Crohn's disease: the Mayo clinic experience in 500 patients

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Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice

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Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease

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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

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Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.

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12 December 2020

Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice

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12 December 2020

A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

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12 December 2020

Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

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12 December 2020

Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells

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12 December 2020

TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53

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12 December 2020

Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

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12 December 2020

Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis

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12 December 2020

Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis

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12 December 2020

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

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12 December 2020

Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.

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12 December 2020

10.1111/J.1365-2567.2006.02349.X

Identifiers

DOI

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19 January 2020

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