Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance (Q83864443)

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28 January 2020

title

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance (English)

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28 January 2020

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1

Mihai G Netea

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28 January 2020

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Leo A B Joosten

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Bart Jan Kullberg

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28 January 2020

Jos W. M. van der Meer,

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object named as

Jos W M van der Meer

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28 January 2020

author name string

Eli Lewis

3

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Dalan R Jensen

4

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Peter J Voshol

5

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Cees J Tack

7

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Han van Krieken

8

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Soo-Hyun Kim

9

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Anton F Stalenhoef

10

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Fons A van de Loo

11

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Ineke Verschueren

12

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Leslie Pulawa

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Shizuo Akira

14

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Robert H Eckel

15

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Charles A Dinarello

16

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Wim van den Berg

17

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publication date

28 May 2006

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number of pages

7

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inferred from page(s)

published in

Nature Medicine

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volume

12

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page(s)

650-656

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issue

6

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https://scigraph.springernature.com/pub.10.1038/nm1415

28 January 2020

exact match

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cites work

An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis

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7 January 2021

Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.

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7 January 2021

IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family

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7 January 2021

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

1 reference

7 January 2021

Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

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7 January 2021

Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy

1 reference

7 January 2021

Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity.

1 reference

7 January 2021

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

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7 January 2021

Role of insulin resistance in human disease (syndrome X): an expanded definition

1 reference

7 January 2021

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

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7 January 2021

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice

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7 January 2021

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

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7 January 2021

The role of SOCS-3 in leptin signaling and leptin resistance

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7 January 2021

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

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7 January 2021

Central leptin acutely reverses diet-induced hepatic insulin resistance.

1 reference

7 January 2021

IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

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7 January 2021

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice

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7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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7 January 2021

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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7 January 2021

Defective NK cell activity and Th1 response in IL-18-deficient mice

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7 January 2021

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

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7 January 2021

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

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7 January 2021

In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake

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7 January 2021

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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7 January 2021

Identifiers

DOI

10.1038/NM1415

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28 January 2020

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