Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells (Q84623806)

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scientific article published on 26 July 2012

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English	Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells	scientific article published on 26 July 2012

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833345%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833345%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

reactive oxygen species

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pancreatic cancer

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author name string

Yoshihide Shimojo

1

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9 February 2020

Miho Akimoto

2

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9 February 2020

Tsunehiro Hisanaga

3

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9 February 2020

Tsuneo Tanaka

4

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9 February 2020

Yoshitsugu Tajima

5

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9 February 2020

Yoshio Honma

6

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Europe PubMed Central

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9 February 2020

Keizo Takenaga

7

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9 February 2020

publication date

26 July 2012

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9 February 2020

Clinical & Experimental Metastasis

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9 February 2020

30

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9 February 2020

2

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9 February 2020

143-154

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9 February 2020

https://scigraph.springernature.com/pub.10.1007/s10585-012-9519-8

0 references

Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

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Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor- B via c-SRC and Oxidant-Dependent Cell Death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-driven selection of the metastatic phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta and epithelial-to-mesenchymal transitions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Mitochondrial complex III regulates hypoxic activation of HIF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine inhibits endothelial cell invasion and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Trends in the treatment and outcome of pancreatic cancer in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of snail in pancreatic cancer promotes metastasis and chemoresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine -- passe-partout or much ado about nothing?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine: multiple clinical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species and HIF-1 signalling in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vivo xenograft murine human uveal melanoma model develops hepatic micrometastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

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Pancreatic tumors show high levels of hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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The signaling mechanism of ROS in tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 and cancer pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of hypoxia-induced NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer statistics, 2008

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex networks orchestrate epithelial-mesenchymal transitions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

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Commentary: Antioxidants for cancer: new tricks for an old dog?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct regulation of TWIST by HIF-1alpha promotes metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

1 reference

https://pubmed.ncbi.nlm.nih.gov/22833345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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