Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones (Q84880728)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19904799%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones (English)

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12 February 2020

2

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4

Maurizio Botta

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12 February 2020

author name string

Stefano Forli

series ordinal

1

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Karl-Heinz Altmann

series ordinal

3

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12 February 2020

publication date

1 January 2010

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12 February 2020

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12 February 2020

volume

5

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issue

1

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page(s)

35-40

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Refined structure of alpha beta-tubulin at 3.5 A resolution

12 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

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7 January 2021

A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone

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7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

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7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

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https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones

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https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

Design and synthesis of C6-C8 bridged epothilone A.

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7 January 2021

Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution

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7 January 2021

The chemistry and biology of epothilones--the wheel keeps turning.

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7 January 2021

Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition

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7 January 2021

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

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7 January 2021

The biology and medicinal chemistry of epothilones

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7 January 2021

Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity

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7 January 2021

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

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7 January 2021

Chemical Biology of Epothilones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

Scaffolds for microtubule inhibition through extensive modification of the epothilone template

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

Oxidative and reductive transformations of epothilone A

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

Conformational preferences of natural and C3-modified epothilones in aqueous solution

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900303

7 January 2021

Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate

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7 January 2021

Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route

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7 January 2021

Chemical synthesis and biological properties of pyridine epothilones

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200900303

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19904799%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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