Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics (Q87503251)

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scientific article published on 12 July 2014

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English	Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics	scientific article published on 12 July 2014

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12 March 2020

Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics (English)

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Beth L. Thurberg

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Beth L Thurberg

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James M Murray

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Anne Marie Thompson

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Allison Vitsky

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Michael Hawes

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Wei-Lien Chuang

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Joshua Pacheco

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Stephen Wilson

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John M McPherson

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Kenneth P Karey

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Laura Andrews

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12 July 2014

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Molecular Genetics and Metabolism

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Biochemical studies in Niemann-Pick disease. I. Major sphingolipids of liver and spleen

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Type B Niemann-Pick disease: findings at chest radiography, thin-section CT, and pulmonary function testing

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Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

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Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells

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Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy

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Signal transduction of stress via ceramide

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Infusion of recombinant human acid sphingomyelinase into niemann-pick disease mice leads to visceral, but not neurological, correction of the pathophysiology

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Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis

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Induction of tolerance to a recombinant human enzyme, acid alpha-glucosidase, in enzyme deficient knockout mice

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Proinflammatory cytokines

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Interleukin-6 and chronic inflammation

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Depressed heart rate variability is associated with high IL-6 blood level and decline in the blood pressure in septic patients

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The therapeutic potential of modulating the ceramide/sphingomyelin pathway

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Sphingolipid mediators in cardiovascular cell biology and pathology

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7 January 2021

Biologically active sphingolipids in cancer pathogenesis and treatment

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7 January 2021

Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation

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7 January 2021

Downregulation of the HERG (KCNH2) K(+) channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation

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7 January 2021

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

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7 January 2021

Raft ceramide in molecular medicine

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Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

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7 January 2021

Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.

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7 January 2021

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

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High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor

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Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

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Liver and skin histopathology in adults with acid sphingomyelinase deficiency (Niemann-Pick disease type B)

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Identifiers

10.1016/J.YMGME.2014.07.005

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Europe PubMed Central

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12 March 2020

1 reference

Europe PubMed Central

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12 March 2020

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