Biologically active sphingolipids in cancer pathogenesis and treatment (Q35852313)

10 August 2017

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title

Biologically active sphingolipids in cancer pathogenesis and treatment (English)

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10 August 2017

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Besim Ogretmen

1

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PubMed ID

15286740

10 August 2017

Yusuf A Hannun

series ordinal

2

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PubMed ID

15286740

10 August 2017

language of work or name

English

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publication date

1 August 2004

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10 August 2017

Nature Reviews Cancer

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10 August 2017

4

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10 August 2017

604-616

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10 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc1411

10 August 2017

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cites work

Functions of ceramide in coordinating cellular responses to stress

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The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

31 March 2020

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Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance

31 March 2020

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Ceramide in apoptosis signaling: relationship with oxidative stress

31 March 2020

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Ceramide glycosylation potentiates cellular multidrug resistance

31 March 2020

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The structural requirements for ceramide activation of serine-threonine protein phosphatases

31 March 2020

1 reference

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

31 March 2020

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Sphingosine-1-phosphate: dual messenger functions

31 March 2020

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Signaling and biological actions of sphingosine 1-phosphate

31 March 2020

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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

31 March 2020

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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

31 March 2020

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Sphingolipid transport: rafts and translocators.

31 March 2020

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Targeting ceramide metabolism--a strategy for overcoming drug resistance

31 March 2020

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Ceramide levels are inversely associated with malignant progression of human glial tumors.

31 March 2020

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Ceramide in apoptosis: an overview and current perspectives

31 March 2020

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Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria

31 March 2020

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C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells

31 March 2020

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Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

31 March 2020

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FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

31 March 2020

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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

31 March 2020

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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

31 March 2020

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Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry.

31 March 2020

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

31 March 2020

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Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis

31 March 2020

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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

31 March 2020

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Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway

31 March 2020

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Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells

31 March 2020

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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

31 March 2020

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Involvement of FAN in TNF-induced apoptosis

31 March 2020

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Regulation of sphingomyelinases in cells of the oligodendrocyte lineage

31 March 2020

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Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.

31 March 2020

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Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration

31 March 2020

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Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death

31 March 2020

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Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosis

31 March 2020

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Ceramide enables fas to cap and kill.

31 March 2020

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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

31 March 2020

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Regulation of cyclin-dependent kinase 2 activity by ceramide

31 March 2020

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Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells

31 March 2020

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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

31 March 2020

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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

31 March 2020

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Role of ceramide in cellular senescence

31 March 2020

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C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p

31 March 2020

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Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae

31 March 2020

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Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

31 March 2020

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Ceramide, stress, and a "LAG" in aging

31 March 2020

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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells

31 March 2020

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Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

31 March 2020

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Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line

31 March 2020

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Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase

31 March 2020

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An oncogenic role of sphingosine kinase

31 March 2020

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

31 March 2020

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Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

31 March 2020

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Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.

31 March 2020

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Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

31 March 2020

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Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

31 March 2020

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Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity

31 March 2020

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VEGF receptor expression and signaling in human bladder tumors

31 March 2020

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Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).

31 March 2020

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Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

31 March 2020

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Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

31 March 2020

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

31 March 2020

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Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

31 March 2020

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Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

31 March 2020

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Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

31 March 2020

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Ceramide and sphingosine 1-phosphate in anti-cancer therapies.

31 March 2020

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Killing tumours by ceramide-induced apoptosis: a critique of available drugs

31 March 2020

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Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells

31 March 2020

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Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

31 March 2020

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p53-dependent ceramide response to genotoxic stress

31 March 2020

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Tumor response to radiotherapy regulated by endothelial cell apoptosis

31 March 2020

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Glucosylceramide synthase and apoptosis

31 March 2020

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Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

31 March 2020

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SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

31 March 2020

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The involvement of sphingolipids in multidrug resistance

31 March 2020

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Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis

31 March 2020

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Accumulation of glucosylceramides in multidrug-resistant cancer cells

31 March 2020

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Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus.

31 March 2020

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Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

31 March 2020

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Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines

31 March 2020

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Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens

31 March 2020

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The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs

31 March 2020

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The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

31 March 2020

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Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

31 March 2020

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Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells

31 March 2020

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N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells

31 March 2020

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Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

31 March 2020

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Novel ceramide analogs as potential chemotherapeutic agents in breast cancer.

31 March 2020

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Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells

31 March 2020

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Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

31 March 2020

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Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

31 March 2020

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Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility

31 March 2020

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Sphingosine-1-Phosphate in Inhibition of Male Germ Cell Apoptosis in the Human Testis

31 March 2020

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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

31 March 2020

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Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases

31 March 2020

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The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

31 March 2020

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

31 March 2020

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

31 March 2020

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Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment

31 March 2020

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FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells

31 March 2020

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Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

31 March 2020

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Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy

31 March 2020

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Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice

31 March 2020

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Identification of a family of animal sphingomyelin synthases

31 March 2020

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Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells

31 March 2020

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Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

31 March 2020

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Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

31 March 2020

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Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

31 March 2020

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Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest

31 March 2020

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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

31 March 2020

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Sphingosine-1-phosphate: signaling inside and out.

31 March 2020

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Molecular machinery for non-vesicular trafficking of ceramide

31 March 2020

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Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

31 March 2020

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Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels

31 March 2020

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The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

31 March 2020

1 reference

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Identifiers

DOI

10.1038/NRC1411

1 reference

10 August 2017

1 reference

PubMed ID

15286740