Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer (Q88683322)

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26 March 2020

title

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer (English)

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26 March 2020

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17

Leonard M Neckers

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26 March 2020

16

Jane B Trepel

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26 March 2020

author name string

Michael A Moses

1

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26 March 2020

Yeong Sang Kim

2

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26 March 2020

Genesis M Rivera-Marquez

3

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26 March 2020

Nobu Oshima

4

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26 March 2020

Matthew J Watson

5

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26 March 2020

Kristin E Beebe

6

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26 March 2020

Catherine Wells

7

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26 March 2020

Sunmin Lee

8

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26 March 2020

Abbey D Zuehlke

9

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Hao Shao

10

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26 March 2020

William E Bingman

11

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Vineet Kumar

12

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Sanjay V Malhotra

13

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Nancy L Weigel

14

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Jason E Gestwicki

15

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publication date

15 May 2018

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26 March 2020

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volume

78

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issue

14

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page(s)

4022-4035

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Interaction of the 90-kDa heat shock protein with native and in vitro translated androgen receptor and receptor fragments

26 March 2020

cites work

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12 December 2020

Chaperone power in a virus?

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12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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12 December 2020

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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12 December 2020

Mechanisms of androgen receptor activation and function.

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12 December 2020

Immunoaffinity isolation of native membrane glucocorticoid receptor from S-49++ lymphoma cells: biochemical characterization and interaction with Hsp 70 and Hsp 90

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12 December 2020

Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

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12 December 2020

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

1 reference

12 December 2020

The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1

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12 December 2020

Molecular chaperones throughout the life cycle of the androgen receptor

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12 December 2020

Geldanamycin, an inhibitor of Hsp90, blocks cytoplasmic retention of progesterone receptors and glucocorticoid receptors via their respective ligand binding domains

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12 December 2020

Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer

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12 December 2020

Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex

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12 December 2020

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

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12 December 2020

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

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12 December 2020

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

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12 December 2020

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

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12 December 2020

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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12 December 2020

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

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12 December 2020

Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

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12 December 2020

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

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12 December 2020

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

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12 December 2020

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

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12 December 2020

Targeting the dynamic HSP90 complex in cancer

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12 December 2020

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

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12 December 2020

Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival

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12 December 2020

Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers

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12 December 2020

Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality

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12 December 2020

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

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12 December 2020

Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

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12 December 2020

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells.

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12 December 2020

Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression

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12 December 2020

Overcoming mutation-based resistance to antiandrogens with rational drug design

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12 December 2020

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.

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12 December 2020

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators

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12 December 2020

Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents

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12 December 2020

Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade

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12 December 2020

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

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12 December 2020

Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles

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12 December 2020

Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells

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12 December 2020

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

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12 December 2020

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases

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12 December 2020

Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer

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12 December 2020

Are androgen receptor variants a substitute for the full-length receptor?

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12 December 2020

Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

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12 December 2020

Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

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12 December 2020

Androgen Receptor Splice Variants Dimerize to Transactivate Target Genes

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12 December 2020

Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer

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12 December 2020

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.

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12 December 2020

X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition

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12 December 2020

10.1158/0008-5472.CAN-17-3728

Identifiers

DOI

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26 March 2020

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26 March 2020

PubMed publication ID

29764864

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