High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping (Q88741254)

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scientific article published on 17 May 2018

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English	High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping	scientific article published on 17 May 2018

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27 March 2020

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping (English)

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27 March 2020

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Matthias Kretzler

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Matthias Kretzler

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27 March 2020

Jonathan Himmelfarb

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Jonathan Himmelfarb

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27 March 2020

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Stefan M Czerniecki

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27 March 2020

Nelly M Cruz

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27 March 2020

Jennifer L Harder

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27 March 2020

Rajasree Menon

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27 March 2020

James Annis

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Edgar A Otto

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Ramila E Gulieva

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Laura V Islas

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Yong Kyun Kim

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Linh M Tran

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27 March 2020

Timothy J Martins

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27 March 2020

Jeffrey W Pippin

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27 March 2020

Hongxia Fu

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27 March 2020

Stuart J Shankland

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27 March 2020

Randall T Moon

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27 March 2020

Neal Paragas

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27 March 2020

Benjamin S Freedman

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17 May 2018

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27 March 2020

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27 March 2020

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27 March 2020

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27 March 2020

929-940.e4

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27 March 2020

Embryonic stem cell lines derived from human blastocysts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

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Human and porcine early kidney precursors as a new source for transplantation

1 reference

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12 December 2020

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Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

1 reference

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12 December 2020

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Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

1 reference

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12 December 2020

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

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12 December 2020

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Cisplatin nephrotoxicity: mechanisms and renoprotective strategies

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New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening

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Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney

1 reference

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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

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Non-muscle myosin II takes centre stage in cell adhesion and migration

1 reference

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12 December 2020

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

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Genes that confer the identity of the renin cell

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Induced pluripotent stem cells--opportunities for disease modelling and drug discovery

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A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

1 reference

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Transgelin is a marker of repopulating mesangial cells after injury and promotes their proliferation and migration

1 reference

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12 December 2020

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Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension

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Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

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A functional CFTR assay using primary cystic fibrosis intestinal organoids

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Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes

1 reference

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Cerebral organoids model human brain development and microcephaly

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Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.

1 reference

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Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells

1 reference

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Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

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In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

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Generation of functional human pancreatic β cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

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Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

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A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

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Nephron organoids derived from human pluripotent stem cells model kidney development and injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

1 reference

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12 December 2020

based on heuristic

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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

1 reference

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12 December 2020

based on heuristic

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Co-ordinated ocular development from human iPS cells and recovery of corneal function

1 reference

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12 December 2020

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CD146(+) cells are essential for kidney vasculature development.

1 reference

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A High-Throughput Screening Assay to Identify Kidney Toxic Compounds

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1 reference

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1 reference

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1 reference

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12 December 2020

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Psychrophilic proteases dramatically reduce single-cell RNA-seq artifacts: a molecular atlas of kidney development

1 reference

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Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

1 reference

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Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.

1 reference

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Identifiers

10.1016/J.STEM.2018.04.022

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27 March 2020

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27 March 2020

PubMed publication ID

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27 March 2020

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