Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells (Q89998655)

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10 April 2020

title

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells (English)

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10 April 2020

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12

John Blenis

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3

Gina Lee

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10 April 2020

author name string

Yuxiang Zheng

1

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Ting-Yu Lin

2

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Marcia N Paddock

4

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Jessica Momb

5

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Zhe Cheng

6

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Qian Li

7

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10 April 2020

Dennis L Fei

8

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Benjamin D Stein

9

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Shivan Ramsamooj

10

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Guoan Zhang

11

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Lewis C Cantley

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publication date

1 November 2018

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volume

175

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issue

6

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page(s)

1546-1560.e17

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Role of thymidylate synthetase activity in development of methotrexate cytotoxicity

10 April 2020

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Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria

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10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells.

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Trafficking of Intracellular Folates

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Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

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12 December 2020

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Serine one-carbon catabolism with formate overflow

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12 December 2020

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Mitochondrial translation requires folate-dependent tRNA methylation

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12 December 2020

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

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12 December 2020

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12 December 2020

10.1016/J.CELL.2018.09.041

Identifiers

DOI

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10 April 2020

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10 April 2020

PubMed publication ID

30500537

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