Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma (Q90080352)

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scientific article published on 11 September 2019

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English	Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma	scientific article published on 11 September 2019

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scholarly article

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11 April 2020

Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma (English)

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11 April 2020

invasive ductal carcinoma

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inferred from title

pancreatic ductal adenocarcinoma

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pancreatic ductal carcinoma

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based on heuristic

inferred from title

2

object named as

Ru Zhou

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9

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Didier Dreau

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11 April 2020

author name string

Mahboubeh Yazdanifar

1

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Priyanka Grover

3

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Chandra Williams

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Mukulika Bose

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Laura J Moore

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Shu-Ta Wu

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John Maher

8

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And Pinku Mukherjee

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publication date

11 September 2019

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8

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copyright license

Creative Commons Attribution 4.0 International

11 September 2019

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Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2

1 reference

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12 December 2020

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Inhibition of T cell proliferation by macrophage tryptophan catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T-cell activation

1 reference

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based on heuristic

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Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation

1 reference

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based on heuristic

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Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

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Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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MUC1 and MUC2 in pancreatic neoplasia

1 reference

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12 December 2020

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MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation.

1 reference

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Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

1 reference

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

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12 December 2020

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Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

1 reference

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Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

1 reference

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12 December 2020

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Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanoma

1 reference

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based on heuristic

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Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

1 reference

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The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

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12 December 2020

based on heuristic

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The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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Regulation of immune responses by prostaglandin E2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC1 regulates PDGFA expression during pancreatic cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

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The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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Galectin-9 functionally impairs natural killer cells in humans and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-9 in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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Kinetics of tumor destruction by chimeric antigen receptor-modified T cells

1 reference

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

1 reference

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Addressing the challenges of pancreatic cancer: future directions for improving outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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Tryptophan-degrading enzymes in tumoral immune resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

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Engineering CAR-T cells: Design concepts

1 reference

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based on heuristic

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A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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A novel association of neuropilin-1 and MUC1 in pancreatic ductal adenocarcinoma: role in induction of VEGF signaling and angiogenesis

1 reference

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Pancreatic cancer

1 reference

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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

1 reference

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Pancreatic Cancer: A Review

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Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors

1 reference

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12 December 2020

based on heuristic

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Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy

1 reference

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12 December 2020

based on heuristic

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Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

1 reference

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1 reference

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Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cells

1 reference

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based on heuristic

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A tumor specific antibody to aid breast cancer screening in women with dense breast tissue

1 reference

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12 December 2020

based on heuristic

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1 reference

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based on heuristic

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Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles.

1 reference

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based on heuristic

inferred from PubMed ID database lookup

TIM-3, a promising target for cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

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based on heuristic

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CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth.

1 reference

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Identifiers

10.3390/CELLS8091070

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11 April 2020

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11 April 2020

1 reference

Europe PubMed Central

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11 April 2020

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