Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues (Q90678073)

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15 April 2020

title

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues (English)

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15 April 2020

4

Ines Batinic-Haberle

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15 April 2020

2

Carryn M Anderson

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15 April 2020

author name string

Kranti A Mapuskar

1

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15 April 2020

Douglas R Spitz

3

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15 April 2020

Bryan G Allen

5

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15 April 2020

Rebecca E Oberley-Deegan

6

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publication date

1 January 2019

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Seminars in Radiation Oncology

15 April 2020

published in

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volume

29

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issue

1

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15 April 2020

page(s)

72-80

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Cell proliferation and oxidative stress

15 April 2020

cites work

1 reference

12 December 2020

Superoxide dismutase: a comparison of rate constants.

1 reference

12 December 2020

Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity

1 reference

12 December 2020

The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic

1 reference

12 December 2020

Computer-aided design (CAD) of Mn(II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme

1 reference

12 December 2020

Does oxidative damage to DNA increase with age?

1 reference

12 December 2020

Free radicals in the physiological control of cell function

1 reference

12 December 2020

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

1 reference

12 December 2020

Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity

1 reference

12 December 2020

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

1 reference

12 December 2020

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

1 reference

12 December 2020

New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins

1 reference

12 December 2020

Palifermin for oral mucositis after intensive therapy for hematologic cancers

1 reference

12 December 2020

A mechanism-based antioxidant approach for the reduction of skin carcinogenesis

1 reference

12 December 2020

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

1 reference

12 December 2020

Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma

1 reference

12 December 2020

A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state.

1 reference

12 December 2020

Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis

1 reference

12 December 2020

Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages

1 reference

12 December 2020

Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies

1 reference

12 December 2020

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

1 reference

12 December 2020

Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters.

1 reference

12 December 2020

Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice

1 reference

12 December 2020

Evaluating the supportive care costs of severe radiochemotherapy-induced mucositis and pharyngitis : results from a Northwestern University Costs of Cancer Program pilot study with head and neck and nonsmall cell lung cancer patients who received ca

1 reference

12 December 2020

Radiation treatment breaks and ulcerative mucositis in head and neck cancer

1 reference

12 December 2020

Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life

1 reference

12 December 2020

Redox control of the cell cycle in health and disease

1 reference

12 December 2020

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor

1 reference

12 December 2020

Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: the University of Wisconsin experience.

1 reference

12 December 2020

Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

1 reference

12 December 2020

Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage

1 reference

12 December 2020

The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation

1 reference

12 December 2020

Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage

1 reference

12 December 2020

Palifermin Decreases Severe Oral Mucositis of Patients Undergoing Postoperative Radiochemotherapy for Head and Neck Cancer: A Randomized, Placebo-Controlled Trial

1 reference

12 December 2020

Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study

1 reference

12 December 2020

Redox regulation of mitochondrial function

1 reference

12 December 2020

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

1 reference

12 December 2020

Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells

1 reference

12 December 2020

The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation

1 reference

12 December 2020

Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.

1 reference

12 December 2020

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

1 reference

12 December 2020

The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation: a single-center, randomized, prospective study of a calcium phosphate mouth rinse + sta

1 reference

12 December 2020

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

1 reference

12 December 2020

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum

1 reference

12 December 2020

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.

1 reference

12 December 2020

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

1 reference

12 December 2020

Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]).

1 reference

12 December 2020

Multi-institutional, randomized, double-blind, placebo-controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head an

1 reference

12 December 2020

Phase II multicenter trial of Caphosol for the reduction of mucositis in patients receiving radiation therapy for head and neck cancer

1 reference

12 December 2020

Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways

1 reference

12 December 2020

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

1 reference

12 December 2020

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells

1 reference

12 December 2020

Morphine mouthwash for the management of oral mucositis in patients with head and neck cancer

1 reference

12 December 2020

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways

1 reference

12 December 2020

Anticancer therapeutic potential of Mn porphyrin/ascorbate system

1 reference

12 December 2020

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

1 reference

12 December 2020

Mitochondrial Quality Control as a Therapeutic Target

1 reference

12 December 2020

Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients.

1 reference

12 December 2020

MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene

1 reference

12 December 2020

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells

1 reference

12 December 2020

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier

1 reference

12 December 2020

A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.

1 reference

12 December 2020

MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway

1 reference

12 December 2020

A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function

1 reference

12 December 2020

Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.

1 reference

12 December 2020

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

1 reference

12 December 2020

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

1 reference

12 December 2020

The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues

1 reference

12 December 2020

Phase 1b/2a Trial of the Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-Induced Oral Mucositis in Patients With Oral Cavity or Oropharyngeal Carcinoma.

1 reference

12 December 2020

Phase II investigational oral drugs for the treatment of radio/chemotherapy induced oral mucositis

1 reference

12 December 2020

The Addition of Manganese Porphyrins during Radiation Inhibits Prostate Cancer Growth and Simultaneously Protects Normal Prostate Tissue from Radiation Damage

1 reference

12 December 2020

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

1 reference

12 December 2020

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.

1 reference

12 December 2020

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury

1 reference

12 December 2020

10.1016/J.SEMRADONC.2018.10.005

Identifiers

DOI

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15 April 2020

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15 April 2020

PubMed publication ID

30573187

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