Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening (Q92097181)

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title

Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening (English)

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(5E,8R,9E)-3-(2-amino-2-oxoethyl)-8,10-dimethyl-7-oxododeca-5,9,11-trienoic acid

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inferred from

reverse claim

4-[(2E,5R,6E)-5,7-dimethyl-4-oxonona-2,6,8-trienyl]piperidine-2,6-dione

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4-[(5R,6E)-5,7-dimethyl-4-oxonona-6,8-dienyl]piperidine-2,6-dione

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inferred from

reverse claim

methyl (5E,8R,9E)-3-(2-amino-2-oxoethyl)-8,10-dimethyl-7-oxododeca-5,9,11-trienoate

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6

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Jong Seog Ahn

10

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Jae-Hyuk Jang

12

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Young-Soo Hong

13

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11

Bang Yeon Hwang

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author name string

Byeongsan Lee

1

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Sangkeun Son

2

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Jae Kyoung Lee

3

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Mina Jang

4

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Kyung Taek Heo

5

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Dong-Jin Park

7

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Chan Sun Park

8

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Chang-Jin Kim

9

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publication date

18 December 2019

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The Journal of Antibiotics

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published in

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volume

73

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issue

3

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page(s)

184-188

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describes a project that uses

26 April 2020

liquid chromatography–mass spectrometry

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Understanding and manipulating antibiotic production in actinomycetes

inferred from title

cites work

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7 January 2021

Actinomycetes: still a source of novel antibiotics

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Dereplication of microbial extracts and related analytical technologies

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Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library.

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Biosynthesis of polyketides by trans-AT polyketide synthases

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

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Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

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The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis

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Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities.

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7 January 2021

Studies on a new antiviral antibiotic, 9-methylstreptimidone. I. Physicochemical and biological properties.

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7 January 2021

Isolation, antifungal activity, and structure elucidation of the glutarimide antibiotic, streptimidone, produced by Micromonospora coerulea

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7 January 2021

Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin

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7 January 2021

Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation

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7 January 2021

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

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7 January 2021

Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase

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7 January 2021

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

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7 January 2021

Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity

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7 January 2021

Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching

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7 January 2021

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

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7 January 2021

10.1038/S41429-019-0264-Y

Identifiers

DOI

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26 April 2020

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