A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping (Q95656974)

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28 May 2020

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13 July 2022

22 October 2022

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping (English)

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28 May 2020

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28 May 2020

author name string

Alessia Ruggiero

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28 May 2020

Flavia Squeglia

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28 May 2020

Giovanni Maga

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Rita Berisio

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20 May 2020

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28 May 2020

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2 references

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Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

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Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.

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High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

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Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

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Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

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Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers.

14 October 2020

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Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

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Comparison of super-secondary structures in proteins

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RNA methyltransferases involved in 5' cap biosynthesis

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Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase.

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Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP.

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RNA helicases--one fold for many functions

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Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase

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Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5'-triphosphatase activities

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Mechanism of nucleic acid unwinding by SARS-CoV helicase.

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The coronavirus replicase.

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The predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.

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Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase

14 October 2020

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Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

14 October 2020

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Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.

14 October 2020

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SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

14 October 2020

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Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs

14 October 2020

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The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids

14 October 2020

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Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

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Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

14 October 2020

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Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

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2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

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The broad-spectrum antiviral functions of IFIT and IFITM proteins

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Mouse hepatitis virus nucleocapsid protein as a translational effector of viral mRNAs

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Coronavirus particle assembly: primary structure requirements of the membrane protein

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Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein

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1 reference

https://api.crossref.org/works/10.3390/CELLS9051267

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

14 October 2020

1 reference

https://api.crossref.org/works/10.3390/CELLS9051267

The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction

14 October 2020

1 reference

https://api.crossref.org/works/10.3390/CELLS9051267

Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid

14 October 2020

1 reference

https://api.crossref.org/works/10.3390/CELLS9051267

14 October 2020

Identifiers

DOI

10.3390/CELLS9051267

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32443810%20AND%20SRC:MED&resulttype=core&format=json

28 May 2020

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32443810%20AND%20SRC:MED&resulttype=core&format=json