Protein phosphatase 2A dysfunction in Alzheimer's disease (Q21090465)

Europe PubMed Central

title

Protein phosphatase 2A dysfunction in Alzheimer's disease (English)

0 references

1 reference

Jean-Marie Sontag

1

Jean-Marie

Sontag

1 reference

PubMed publication ID

24653673

9 August 2022

Estelle Sontag

series ordinal

2

author given names

Estelle

author last names

Sontag

1 reference

PubMed publication ID

24653673

Frontiers in Molecular Neuroscience

9 August 2022

language of work or name

English

0 references

publication date

2014

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published in

1 reference

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

volume

7

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page(s)

16

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cites work

1 reference

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Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

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Protein phosphatase 2A: the Trojan Horse of cellular signaling

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A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle

12 September 2017

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Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites

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Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

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Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation

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Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules

27 September 2017

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30 May 2018

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30 May 2018

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30 May 2018

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S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice.

21 January 2018

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Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology

21 January 2018

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Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

21 January 2018

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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

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PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.

21 January 2018

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Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease

21 January 2018

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Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons

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Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels

21 January 2018

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Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

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The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

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Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2014.00016

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2014.00016

Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2014.00016

Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2014.00016

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2014.00016

Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949405

Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949405

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3949405

Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24653673

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/24653673

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FNMOL.2014.00016

1 reference

1 reference

1 reference

PubMed publication ID

24653673

1 reference