Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. (Q33952539)

30 July 2017

Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. (English)

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30 July 2017

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Jean-Michel Wieruszeski

5

Jean-Michel Wieruszeski

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Caroline Smet

2

Caroline Smet-Nocca

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Laziza Amniai

3

Laziza Amniai

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Isabelle Landrieu

Isabelle Landrieu

1

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Veerle Janssens

Veerle Janssens

7

0 references

Guy Lippens

Guy Lippens

8

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author name string

Laziza Amniai

3

1 reference

30 July 2017

Justin Vijay Louis

4

1 reference

30 July 2017

Jozef Goris

6

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30 July 2017

language of work or name

English

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publication date

23 June 2011

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30 July 2017

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30 July 2017

6

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30 July 2017

e21521

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30 July 2017

6

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Creative Commons Attribution 4.0 International

30 July 2017

start time

23 June 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta

1 reference

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The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

5 July 2018

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Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

5 July 2018

1 reference

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NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease

5 July 2018

1 reference

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Live cell imaging of cytoskeletal dynamics in neurons using fluorescence photoactivation.

5 July 2018

1 reference

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No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

5 July 2018

1 reference

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Unlimited multistability in multisite phosphorylation systems

5 July 2018

1 reference

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From promiscuity to precision: protein phosphatases get a makeover

5 July 2018

1 reference

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Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

NMR investigation of the interaction between the neuronal protein tau and the microtubules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Methods for preparation of proteins and protein complexes that regulate the eukaryotic cell cycle for structural studies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Stimulation of phosphorylase phosphatase activity of protein phosphatase 2A1 by protamine is ionic strength dependent and involves interaction of protamine with both substrate and enzyme.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

NMR analysis of a Tau phosphorylation pattern.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

NMR observation of Tau in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121875

Accepting its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein

29 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Studying Posttranslational Modifications by In-Cell NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

21 January 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021521

21 January 2018

12 December 2020

Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin

1 reference

12 December 2020

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase

1 reference

12 December 2020

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

1 reference

12 December 2020

Purification and properties of polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscle

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0021521

Identifiers

DOI

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30 July 2017

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30 July 2017

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