Interferon gamma inducible protein 16 (Q21097293)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

interferon-gamma induced protein IFI 16
gamma-interferon-inducible protein 16
IFI16 beta isoform
interferon-inducible myeloid differentiation transcriptional activator
IFI16

Language	Label	Description	Also known as
English	Interferon gamma inducible protein 16	mammalian protein found in Homo sapiens	interferon-gamma induced protein IFI 16 gamma-interferon-inducible protein 16 IFI16 beta isoform interferon-inducible myeloid differentiation transcriptional activator IFI16

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

2 references

17 October 2017

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

identical protein binding

determination method

double-stranded DNA binding

determination method

1 reference

1 January 2018

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

transcription factor binding

determination method

protein binding

determination method

7 references

1 January 2018

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

IFI16 is an innate immune sensor for intracellular DNA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

6 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

2 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

17 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

determination method

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

biological process

positive regulation of type I interferon production

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

positive regulation of cytokine production

determination method

1 reference

1 January 2018

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

intrinsic apoptotic signaling pathway by p53 class mediator

determination method

1 reference

1 January 2018

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

cellular response to glucose starvation

determination method

1 reference

1 January 2018

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

negative regulation of viral genome replication

determination method

1 reference

1 January 2018

The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

negative regulation of innate immune response

determination method

1 reference

1 January 2018

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

monocyte differentiation

determination method

1 reference

1 January 2018

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

cellular response to ionizing radiation

determination method

1 reference

1 January 2018

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

negative regulation of DNA binding

determination method

1 reference

1 January 2018

The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

regulation of autophagy

determination method

1 reference

1 January 2018

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

myeloid cell differentiation

determination method

1 reference

1 January 2018

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

determination method

1 reference

1 January 2018

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

apoptotic process

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

activation of cysteine-type endopeptidase activity

determination method

1 reference

1 January 2018

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

negative regulation of cysteine-type endopeptidase activity

determination method

1 reference

1 January 2018

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

1 January 2018

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

positive regulation of interleukin-1 beta production

determination method

1 reference

1 January 2018

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

regulation of transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

regulation of gene expression, epigenetic

determination method

1 reference

1 January 2018

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

cell population proliferation

determination method

1 reference

1 January 2018

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

positive regulation of transcription by RNA polymerase II

determination method

activation of innate immune response

determination method

1 reference

17 October 2017

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16666&geneProductId=UniProtKB:Q16666

determination method

immune system process

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

inflammatory response

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

The human interferon-inducible protein, IFI 16, is a repressor of transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

innate immune response

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

defense response to virus

determination method

1 reference

1 January 2018

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

cellular response to interferon-beta

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16666

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000295809

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000295809

ENSP00000352740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352740

ENSP00000357113

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357113

ENSP00000357114

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357114

ENSP00000404325

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404325

ENSP00000342741

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342741

ENSP00000406406

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406406

ENSP00000407052

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407052

ENSP00000456094

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456094

ENSP00000456129

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456129

ENSP00000458084

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458084

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21097293&oldid=2022912662"