Mitochondrial antiviral signaling protein (Q21104831)

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mammalian protein found in Homo sapiens
  • IPS-1
  • interferon beta promoter stimulator protein 1
  • CARD adapter inducing interferon beta
  • Cardif
  • mitochondrial antiviral-signaling protein
  • MAVS
  • IFN-B promoter stimulator 1
  • putative NF-kappa-B-activating protein 031N
  • VISA
  • virus-induced signaling adaptor
  • CARD adaptor inducing IFN-beta
  • virus-induced-signaling adapter
edit
Language Label Description Also known as
English
Mitochondrial antiviral signaling protein
mammalian protein found in Homo sapiens
  • IPS-1
  • interferon beta promoter stimulator protein 1
  • CARD adapter inducing interferon beta
  • Cardif
  • mitochondrial antiviral-signaling protein
  • MAVS
  • IFN-B promoter stimulator 1
  • putative NF-kappa-B-activating protein 031N
  • VISA
  • virus-induced signaling adaptor
  • CARD adaptor inducing IFN-beta
  • virus-induced-signaling adapter

Statements

molecular function
protein binding
determination method
IPI
48 references
retrieved
17 October 2017
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Mitochondrially localised MUL1 is a novel modulator of antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q7Z434
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Nlrp6 regulates intestinal antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
MAVS protein is attenuated by rotavirus nonstructural protein 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Activation of STAT6 by STING is critical for antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
NLRX1 is a regulator of mitochondrial antiviral immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The Atg5 Atg12 conjugate associates with innate antiviral immune responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
retrieved
17 October 2017
stated in
Novel function of Trim44 promotes an antiviral response by stabilizing VISA.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z434&geneProductId=UniProtKB:Q7Z434
determination method
IPI
cell component
biological process

Identifiers

 
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