Sirtuin 4 (Q21104987)

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mammalian protein found in Homo sapiens

NAD-dependent ADP-ribosyltransferase sirtuin-4
NAD-dependent protein deacetylase sirtuin-4
3.5.1.-
SIRT4
regulatory protein SIR2 homolog 4
sirtuin type 4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
SIR2-like protein 4
2.4.2.-
sir2-like 4

Language	Label	Description	Also known as
English	Sirtuin 4	mammalian protein found in Homo sapiens	NAD-dependent ADP-ribosyltransferase sirtuin-4 NAD-dependent protein deacetylase sirtuin-4 3.5.1.- SIRT4 regulatory protein SIR2 homolog 4 sirtuin type 4 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIR2-like protein 4 2.4.2.- sir2-like 4

Statements

1 reference

13 November 2019

UniProt protein ID

Sirtuin, class II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E7

DHS-like NAD/FAD-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E7

Sirtuin, catalytic core small domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E7

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

NAD-dependent protein deacetylase activity

determination method

1 reference

8 April 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

protein binding

determination method

5 references

8 April 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

determination method

2 references

NAD+ ADP-ribosyltransferase activity

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Sirtuin functions in health and disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

biotinidase activity

determination method

1 reference

8 April 2019

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

zinc ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

mitochondrial inner membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

mitochondrial matrix

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

biological process

protein ADP-ribosylation

determination method

5 references

8 April 2019

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Sirtuin functions in health and disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

regulation of glutamine family amino acid metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

negative regulation of fatty acid oxidation

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

cellular response to DNA damage stimulus

determination method

negative regulation of protein processing involved in protein targeting to mitochondrion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

negative regulation of cardiac muscle cell apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

cellular response to hypoxia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

mitochondrion organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

protein deacetylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E7

determination method

EC enzyme number

2.4.2.-

1 reference

14 November 2015

http://www.uniprot.org/uniprot/Q9Y6E7.txt?version=124

Sirtuin family, catalytic core domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E7

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000202967

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000202967

ENSP00000444838

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444838

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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