Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins (Q24312912)

Sirtuin 6

1 reference

sirtuin 3

1 reference

sirtuin 1

1 reference

Sirtuin 5

1 reference

Sirtuin 2

1 reference

Sirtuin 4

1 reference

author name string

Eriko Michishita

1

0 references

Jean Y Park

2

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Jenna M Burneskis

3

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J Carl Barrett

4

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Izumi Horikawa

Molecular Biology of the Cell

5

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language of work or name

English

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publication date

October 2005

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published in

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volume

16

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page(s)

4623-35

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issue

10

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cites work

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

19 March 2017

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

19 March 2017

1 reference

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

19 March 2017

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

19 March 2017

1 reference

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Sirtuins: Sir2-related NAD-dependent protein deacetylases

19 March 2017

1 reference

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

19 March 2017

1 reference

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Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state

19 March 2017

1 reference

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

19 March 2017

1 reference

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19 March 2017

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Negative control of p53 by Sir2alpha promotes cell survival under stress

19 March 2017

1 reference

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

19 March 2017

1 reference

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

19 March 2017

1 reference

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Extension of life-span by introduction of telomerase into normal human cells

19 March 2017

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Localization of Sir2p: the nucleolus as a compartment for silent information regulators

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

The Sir2 family of protein deacetylases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Mammalian SIRT1 represses forkhead transcription factors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

DNA damage activates p53 through a phosphorylation-acetylation cascade

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

p53 moves to mitochondria: a turn on the path to apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Oxidative stress and mitochondrial function with aging--the effects of calorie restriction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Calorie restriction and aging: review of the literature and implications for studies in humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Genetics of cellular senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Telomere dysfunction: multiple paths to the same end.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Model organisms as a guide to mammalian aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

From cells to organisms: can we learn about aging from cells in culture?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Induction of cellular senescence in immortalized cells by human chromosome 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

p53 in the cytoplasm: a question of overkill?

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Mechanisms of silencing in Saccharomyces cerevisiae.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237069

Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16079181

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E05-01-0033

1 reference

478667

478667

1 reference

1 reference

1 reference