Sirtuin functions in health and disease (Q24303857)

Europe PubMed Central

title

Sirtuin functions in health and disease (English)

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main subject

Sirtuin 6

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sirtuin 3

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sirtuin 1

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Sirtuin 5

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Sirtuin 2

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Sirtuin 4

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protein ADP-ribosylation

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Caloric intake and the risk of Alzheimer disease.

author

Johan Auwerx

series ordinal

3

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Kristina Schoonjans

series ordinal

2

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author name string

Hiroyasu Yamamoto

series ordinal

1

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language of work or name

English

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publication date

August 2007

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published in

Molecular Endocrinology

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volume

21

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page(s)

1745-55

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issue

8

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cites work

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

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Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

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Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

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The retardation of aging by caloric restriction: its significance in the transgenic era.

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Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

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Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

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Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

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Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w).

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Extrachromosomal rDNA circles--a cause of aging in yeast

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An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

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A conserved regulatory system for aging

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7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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7 January 2021

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

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7 January 2021

The molecular biology of the SIR proteins

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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7 January 2021

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

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7 January 2021

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

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7 January 2021

Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The energetics of Huntington's disease

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Requirement of mammalian DNA polymerase-beta in base-excision repair.

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Structure of the histone deacetylase SIRT2

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Resveratrol improves health and survival of mice on a high-calorie diet

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

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7 January 2021

Calorie restriction, SIRT1 and metabolism: understanding longevity

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7 January 2021

Splicing regulates NAD metabolite binding to histone macroH2A.

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Altered sirtuin expression is associated with node-positive breast cancer

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The role of the tumor suppressor p53 in spermatogenesis

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7 January 2021

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

14-3-3 proteins; bringing new definitions to scaffolding

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7 January 2021

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

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https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

1 reference

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7 January 2021

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Calorie restriction extends yeast life span by lowering the level of NADH.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Small molecule regulation of Sir2 protein deacetylases

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Axonal self-destruction and neurodegeneration

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

HST2 mediates SIR2-independent life-span extension by calorie restriction

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Hormonal control of androgen receptor function through SIRT1

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

The Sir2 family of protein deacetylases

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

PPAR(gamma) and glucose homeostasis

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021

Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death.

1 reference

https://api.crossref.org/works/10.1210%2FME.2007-0079

7 January 2021