Itchy E3 ubiquitin protein ligase (Q21109507)

WW domain superfamily

1 reference

C2 domain superfamily

1 reference

E3 ubiquitin-protein ligase, SMURF1 type

1 reference

HECT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

CXCR chemokine receptor binding

1 reference

8 April 2019

The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

22 references

8 April 2019

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The E3 ubiquitin ligase Itch controls the protein stability of p63

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ribonucleoprotein complex binding

1 reference

8 April 2019

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin-like protein transferase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin protein ligase activity

ubiquitin-protein transferase activity

4 references

8 April 2019

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin-like protein ligase binding

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

arrestin family protein binding

1 reference

8 April 2019

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin protein ligase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

3 references

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

early endosome membrane

1 reference

8 April 2019

protein-containing complex

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

HDA

biological process

Notch signaling pathway

1 reference

8 April 2019

protein K29-linked ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

immune system process

1 reference

8 April 2019

protein K63-linked ubiquitination

negative regulation of apoptotic process

1 reference

8 April 2019

The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

defense response to virus

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

regulation of cell growth

1 reference

8 April 2019

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

viral entry into host cell

NAS

1 reference

8 April 2019

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

negative regulation of type I interferon production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

nucleotide-binding oligomerization domain containing signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

innate immune response

1 reference

8 April 2019

protein polyubiquitination

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

positive regulation of T cell anergy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin-dependent protein catabolic process

4 references

31 October 2017

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

The ubiquitin-protein ligase Itch regulates p73 stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

positive regulation of protein catabolic process

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

negative regulation of alpha-beta T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

regulation of hematopoietic stem cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

protein ubiquitination

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

31 October 2017

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02

protein autoubiquitination

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

positive regulation of receptor catabolic process

IMP

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

ubiquitin-dependent protein catabolic process

IMP

5 references

8 April 2019

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

protein ubiquitination

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

protein K29-linked ubiquitination

3 references

8 April 2019

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

protein K63-linked ubiquitination

3 references

8 April 2019

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

protein K48-linked ubiquitination

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02

1 reference

WW domain

1 reference

HECT domain

1 reference

Identifiers

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

12 April 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016