The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation (Q24296068)

Mitogen-activated protein kinase kinase kinase 7

1 reference

Itchy, E3 ubiquitin protein ligase

1 reference

TNF receptor-associated factor 2

1 reference

author name string

Neesar Ahmed

1

0 references

Minghui Zeng

2

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Indrajit Sinha

3

0 references

Lisa Polin

4

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Wei-Zen Wei

5

0 references

Chozhavendan Rathinam

6

0 references

Richard Flavell

7

0 references

Ramin Massoumi

8

0 references

K Venuprasad

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

9

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language of work or name

English

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publication date

December 2011

0 references

published in

Nature Immunology

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volume

12

0 references

page(s)

1176-83

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issue

12

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cites work

1 reference

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The tumor suppressor CYLD regulates entry into mitosis

19 March 2017

1 reference

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Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

19 March 2017

1 reference

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

19 March 2017

1 reference

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

19 March 2017

1 reference

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

19 March 2017

1 reference

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Immunity, Inflammation, and Cancer

19 March 2017

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Cancer-related inflammation

19 March 2017

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NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

19 March 2017

1 reference

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

19 March 2017

1 reference

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

19 March 2017

1 reference

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

19 March 2017

1 reference

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Shared principles in NF-kappaB signaling

19 March 2017

1 reference

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Macrophage diversity enhances tumor progression and metastasis

7 April 2017

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Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

7 April 2017

1 reference

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Ubiquitin makes its mark on immune regulation

27 September 2017

1 reference

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Deubiquitinases in the regulation of NF-κB signaling

27 September 2017

1 reference

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Cbl-b and itch: key regulators of peripheral T-cell tolerance

27 September 2017

1 reference

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Ubiquitin chain cleavage: CYLD at work

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

27 September 2017

1 reference

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Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

27 September 2017

1 reference

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Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway

27 September 2017

1 reference

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Immunotherapy in non-small-cell lung carcinoma: from inflammation to vaccination

27 September 2017

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Ubiquitylation in innate and adaptive immunity.

27 September 2017

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Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339)

27 September 2017

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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice

27 September 2017

1 reference

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

27 September 2017

1 reference

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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

A cytokine-mediated link between innate immunity, inflammation, and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Negative regulation of JNK signaling by the tumor suppressor CYLD.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

The IKK NF-kappa B system: a treasure trove for drug development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219826

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNI.2157

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNI.2157

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Randomized Phase II Study of Bortezomib Alone and Bortezomib in Combination With Docetaxel in Previously Treated Advanced Non–Small-Cell Lung Cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2157

1 reference

2783489

2783489

1 reference

1 reference

1 reference