Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal (Q24298764)

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A Greco

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D Mazzà

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G Canettieri

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L Pietrosanti

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P Infante

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S Coni

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M Moretti

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E De Smaele

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E Ferretti

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I Screpanti

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A Gulino

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

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language of work or name

English

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publication date

6 January 2011

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published in

Oncogene

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volume

30

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issue

1

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page(s)

65-76

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cites work

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The ubiquitin-protein ligase Itch regulates p73 stability

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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

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Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

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Gli1 is important for medulloblastoma formation in Ptc1+/- mice

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Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

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WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

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The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation

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Pathways of ubiquitin conjugation.

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