The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells (Q24339510)

Mitogen-activated protein kinase kinase kinase kinase 3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

5

Yi-Ming Chen

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author name string

Huai-Chia Chuang

1

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Joung-Liang Lan

2

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Der-Yuan Chen

3

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Chia-Yu Yang

4

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Ju-Pi Li

6

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Ching-Yu Huang

7

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Pao-En Liu

8

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Xiaohong Wang

9

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Tse-Hua Tan

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

10

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language of work or name

English

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publication date

November 2011

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published in

Nature Immunology

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volume

12

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issue

11

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page(s)

1113-8

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cites work

1 reference

https://api.crossref.org/works/10.1038/NI.2121

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NI.2121

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/NI.2121

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

20 April 2017

1 reference

The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.

20 April 2017

1 reference

ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.

21 January 2018

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The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.

21 January 2018

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A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

21 January 2018

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Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis.

21 January 2018

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Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

21 January 2018

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Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

21 January 2018

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PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis.

21 January 2018

1 reference

Differential requirement for CARMA1 in agonist-selected T-cell development

21 January 2018

1 reference

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery

21 January 2018

1 reference

Mature T cells depend on signaling through the IKK complex.

21 January 2018

1 reference

Differential requirement of PKC-theta in the development and function of natural regulatory T cells

21 January 2018

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Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

21 January 2018

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Regulation of ER stress-induced macroautophagy by protein kinase C.

21 January 2018

1 reference

Protein kinase C theta (PKCtheta): a key player in T cell life and death

21 January 2018

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Protein kinase C-theta mediates negative feedback on regulatory T cell function

21 January 2018

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Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses

21 January 2018

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12 December 2020

Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases

1 reference

12 December 2020

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

1 reference

12 December 2020

Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation

1 reference

12 December 2020