Copper metabolism domain containing 1 (Q21113001)

http://www.ebi.ac.uk/interpro/protein/Q8N668

COMMD1 N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

COMM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

phosphatidylinositol-3,5-bisphosphate binding

1 reference

1 January 2018

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

phosphatidylinositol-3,4-bisphosphate binding

1 reference

1 January 2018

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

phosphatidic acid binding

1 reference

1 January 2018

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

19 references

1 January 2018

A novel role for XIAP in copper homeostasis through regulation of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD proteins, a novel family of structural and functional homologs of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 downregulates the epithelial sodium channel through Nedd4-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD proteins, a novel family of structural and functional homologs of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Identification of Murr1 as a regulator of the human delta epithelial sodium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

identical protein binding

IPI

1 reference

1 January 2018

COMMD proteins, a novel family of structural and functional homologs of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

phosphatidylinositol-4,5-bisphosphate binding

IPI

1 reference

1 January 2018

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

Characterization and copper binding properties of human COMMD1 (MURR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

phosphatidylinositol-3,4,5-trisphosphate binding

1 reference

1 January 2018

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N668&geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

Cul2-RING ubiquitin ligase complex

1 reference

1 January 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

negative regulation of sodium ion transmembrane transport

biological process

regulation of transcription, DNA-templated

IMP

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N668&geneProductId=UniProtKB:Q8N668

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N668&geneProductId=UniProtKB:Q8N668

negative regulation of protein localization to cell surface

1 reference

21 June 2018

COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N668&geneProductId=UniProtKB:Q8N668

plasma membrane to endosome transport

1 reference

1 January 2018

COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

21 June 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N668&geneProductId=UniProtKB:Q8N668

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

negative regulation of NF-kappaB transcription factor activity

3 references

1 January 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD proteins, a novel family of structural and functional homologs of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Characterization of COMMD protein-protein interactions in NF-kappaB signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

positive regulation of protein ubiquitination

Golgi to plasma membrane transport

1 reference

1 January 2018

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

post-translational protein modification

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

positive regulation of protein ubiquitination

TAS

3 references

1 January 2018

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

regulation of proteasomal ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

IMP

copper ion homeostasis

3 references

1 January 2018

1 January 2018

A novel role for XIAP in copper homeostasis through regulation of MURR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

negative regulation of sodium ion transmembrane transport

3 references

1 January 2018

COMMD1 downregulates the epithelial sodium channel through Nedd4-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Identification of Murr1 as a regulator of the human delta epithelial sodium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

negative regulation of protein localization to cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N668

protein ubiquitination

1 reference

1 January 2018

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N668

COMMD1 N-terminal domain

1 reference

stated in

InterPro Release 71.0