Ring finger protein 31 (Q21115401)

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mammalian protein found in Homo sapiens

E3 ubiquitin-protein ligase RNF31
HOIL-1-interacting protein
HOIP
RNF31
zinc in-between-RING-finger ubiquitin-associated domain protein
RING-type E3 ubiquitin transferase RNF31
RING finger protein 31

Language	Label	Description	Also known as
English	Ring finger protein 31	mammalian protein found in Homo sapiens	E3 ubiquitin-protein ligase RNF31 HOIL-1-interacting protein HOIP RNF31 zinc in-between-RING-finger ubiquitin-associated domain protein RING-type E3 ubiquitin transferase RNF31 RING finger protein 31

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger, RanBP2-type superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

PUB-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

E3 ubiquitin-protein ligase RNF31

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

Ubiquitin-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

E3 ubiquitin-protein ligase RNF31, UBA-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

IBR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PUB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RanBP2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

ubiquitin binding

determination method

1 reference

17 October 2017

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

protein binding

determination method

23 references

17 October 2017

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Linear ubiquitination prevents inflammation and regulates immune signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

A ubiquitin ligase complex assembles linear polyubiquitin chains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

ubiquitin protein ligase binding

determination method

1 reference

17 October 2017

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

transferase activity

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

determination method

7 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

A ubiquitin ligase complex assembles linear polyubiquitin chains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Linear ubiquitination prevents inflammation and regulates immune signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

CD40 receptor complex

determination method

1 reference

17 October 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

17 October 2017

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

biological process

positive regulation of protein targeting to mitochondrion

determination method

1 reference

17 October 2017

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

CD40 signaling pathway

determination method

1 reference

17 October 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

regulation of tumor necrosis factor-mediated signaling pathway

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

17 October 2017

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

T cell receptor signaling pathway

determination method

1 reference

17 October 2017

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

protein linear polyubiquitination

determination method

4 references

17 October 2017

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

Linear ubiquitination prevents inflammation and regulates immune signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

17 October 2017

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0

determination method

Zinc finger, RING-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

Zinc finger, RanBP2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

E3 ubiquitin-protein ligase RNF31, UBA-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

Ubiquitin-associated domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96EP0

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000315112

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000315112

ENSP00000453574

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453574

ENSP00000452820

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452820

ENSP00000452972

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452972

ENSP00000453423

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453423

ENSP00000453471

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453471

ENSP00000453595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453595

ENSP00000453601

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453601

ENSP00000453645

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453645

ENSP00000453672

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453672

ENSP00000453948

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453948

ENSP00000454032

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454032

ENSP00000454048

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454048

ENSP00000454140

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454140

ENSP00000496100

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496100

ENSP00000494218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494218

ENSP00000495294

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495294

ENSP00000494683

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494683

ENSP00000495626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495626

ENSP00000496609

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496609

ENSP00000493488

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493488

ENSP00000494011

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494011

ENSP00000494912

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494912

ENSP00000494950

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494950

ENSP00000494317

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494317

ENSP00000495391

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495391

ENSP00000494612

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494612

ENSP00000495306

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495306

ENSP00000499015

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499015

ENSP00000498923

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498923

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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