The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO (Q24321825)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990450

positive regulation of tumor necrosis factor-mediated signaling pathway

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903265

negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903382

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

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Inhibitor of nuclear factor kappa B kinase subunit beta

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OPA1 mitochondrial dynamin like GTPase

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RANBP2-type and C3HC4-type zinc finger containing 1

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Parkin RBR E3 ubiquitin protein ligase

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Ring finger protein 31

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OPA1, mitochondrial dynamin like GTPase

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Parkin RBR E3 ubiquitin protein ligase

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Inhibitor of kappaB kinase gamma

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protein ubiquitination

1 reference

1 reference

17

Daniel Krappmann

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Kamyar Hadian

Kamyar Hadian

5

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Peer-Hendrik Kuhn

Peer-Hendrik Kuhn

10

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Konstanze Winklhofer

Konstanze F Winklhofer

20

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Gunnar Dittmar

Gunnar Dittmar

18

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Stefan F Lichtenthaler

11

Stefan F Lichtenthaler

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Jorg Tatzelt

19

Jörg Tatzelt

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W. Wurst

14

Wolfgang Wurst

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Dietrich Trümbach

15

Dietrich Trümbach

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Regina Peis

7

Regina Peis

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Elisa Motori

Elisa Motori

12

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author name string

Anne Kathrin Müller-Rischart

1

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Anna Pilsl

2

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Patrick Beaudette

3

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Maria Patra

4

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Maria Funke

6

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Alexandra Deinlein

8

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Carolin Schweimer

9

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Silvana Hrelia

13

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Thomas Langer

The role of parkin in familial and sporadic Parkinson's disease

16

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language of work or name

English

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publication date

7 March 2013

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published in

Molecular Cell

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volume

49

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issue

5

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page(s)

908-21

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Diverse ubiquitin signaling in NF-κB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Linear ubiquitination prevents inflammation and regulates immune signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

A ubiquitin ligase complex assembles linear polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2013.01.036

7 January 2021