The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity (Q28118489)

4 January 2017

title

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity (English)

1 reference

SHANK associated RH domain interactor

4 January 2017

0 references

1 reference

OTU deubiquitinase with linear linkage specificity

1 reference

RANBP2-type and C3HC4-type zinc finger containing 1

1 reference

Ring finger protein 31

1 reference

OTU deubiquitinase with linear linkage specificity

1 reference

author

Rune Busk Damgaard

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Neil V Morgan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Paul R Elliott

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

8

Eamonn R Maher

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

10

David Komander

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Paola Marco-Casanova

3

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Duncan McHale

7

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Jennifer A Walker

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hannah L Titheradge

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Andrew N J McKenzie

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

25 August 2016

1 reference

4 January 2017

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27523608%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

166

2 references

4 January 2017

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12 June 2020

issue

5

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4 January 2017

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12 June 2020

page(s)

1215-1230.e20

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

12 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

Linear ubiquitination prevents inflammation and regulates immune signalling

20 March 2017

1 reference

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

20 March 2017

1 reference

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

20 March 2017

1 reference

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The role of ubiquitylation in immune defence and pathogen evasion

20 March 2017

1 reference

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Molecular Basis and Regulation of OTULIN-LUBAC Interaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

20 March 2017

1 reference

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Fiji: an open-source platform for biological-image analysis

20 March 2017

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The Sequence Alignment/Map format and SAMtools

6 April 2017

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Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma

20 March 2017

1 reference

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CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

20 March 2017

1 reference

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20 March 2017

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

20 March 2017

1 reference

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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

7 April 2017

1 reference

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SHARPIN controls the development of regulatory T cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5002269

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

29 September 2017

1 reference

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Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR.

29 September 2017

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Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.

29 September 2017

1 reference

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Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

29 September 2017

1 reference

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Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

29 September 2017

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

29 September 2017

1 reference

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Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

29 September 2017

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29 September 2017

1 reference

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

29 September 2017

1 reference

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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

29 September 2017

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Regulation of NF-κB by deubiquitinases

29 September 2017

1 reference

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BAFF and MyD88 signals promote a lupuslike disease independent of T cells

29 September 2017

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Testing gene function early in the B cell lineage in mb1-cre mice

29 September 2017

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Cachexia: pathophysiology and clinical relevance

29 September 2017

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Germline FH mutations presenting with pheochromocytoma.

29 September 2017

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Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.

2 June 2018

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2 June 2018

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HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

2 June 2018

1 reference

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Linear ubiquitin chains: NF-κB signalling, cell death and beyond.

27 November 2018

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Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation.

27 November 2018

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

27 November 2018

1 reference

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Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues

27 November 2018

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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

27 November 2018

1 reference

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Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

27 November 2018

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10.1016/J.CELL.2016.07.019

27 November 2018

Identifiers

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12 June 2020

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