RPTOR independent companion of MTOR complex 2 (Q21116071)

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mammalian protein found in Homo sapiens

AVO3 homolog
hAVO3
pianissimo
TORC2-specific protein AVO3
rapamycin-insensitive companion of mTOR
RICTOR
Rapamycin-Insensitive Companion of mTOR Protein

Language	Label	Description	Also known as
English	RPTOR independent companion of MTOR complex 2	mammalian protein found in Homo sapiens	AVO3 homolog hAVO3 pianissimo TORC2-specific protein AVO3 rapamycin-insensitive companion of mTOR RICTOR Rapamycin-Insensitive Companion of mTOR Protein

Statements

1 reference

13 November 2019

UniProt protein ID

Pianissimo family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Rapamycin-insensitive companion of mTOR, domain 4, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rapamycin-insensitive companion of mTOR, domain 5, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rapamycin-insensitive companion of mTOR, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rapamycin-insensitive companion of mTOR, middle domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ribosome binding

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

protein binding

determination method

19 references

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Activation of mTORC2 by association with the ribosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

enzyme activator activity

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

determination method

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

31 October 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

31 October 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

31 October 2017

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

determination method

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

biological process

regulation of protein phosphorylation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

actin cytoskeleton reorganization

determination method

1 reference

31 October 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

positive regulation of endothelial cell proliferation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

positive regulation of actin filament polymerization

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

regulation of actin cytoskeleton organization

determination method

1 reference

31 October 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

determination method

regulation of GTPase activity

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

establishment or maintenance of actin cytoskeleton polarity

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

multicellular organism development

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

peptidyl-serine phosphorylation

determination method

1 reference

1 January 2018

A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

regulation of peptidyl-serine phosphorylation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

establishment of cell polarity

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

regulation of inflammatory response

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

regulation of gene expression

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

regulation of establishment of cell polarity

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

positive regulation of TOR signaling

determination method

1 reference

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

activation of protein kinase B activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

determination method

actin cytoskeleton reorganization

determination method

Rapamycin-insensitive companion of mTOR, domain 4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Rapamycin-insensitive companion of mTOR, domain 5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Rapamycin-insensitive companion of mTOR, phosphorylation-site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Rapamycin-insensitive companion of mTOR, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Rapamycin-insensitive companion of mTOR, middle domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6R327

Identifiers

MeSH descriptor ID

subject named as

Rapamycin-Insensitive Companion of mTOR Protein

0 references

D05.500.356.500

0 references

D08.811.913.696.620.682.700.931.750.500

0 references

D12.644.360.024.323

0 references

D12.776.157.057.156

0 references

D12.776.476.024.411

0 references

D12.776.476.563.931.750.500

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000296782

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000296782

ENSP00000349959

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349959

ENSP00000423019

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423019

ENSP00000423162

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423162

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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