PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription (Q24336209)

MTOR associated protein, LST8 homolog

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mechanistic target of rapamycin kinase

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RPTOR independent companion of MTOR complex 2

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Telomere maintenance 2

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PIH1 domain containing 1

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positive regulation of TORC2 signaling

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author name string

Yuya Kamano

1

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Makio Saeki

2

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Hiroshi Egusa

3

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Yoshito Kakihara

4

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Walid A Houry

5

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Hirofumi Yatani

6

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Yoshinori Kamisaki

Initiating cellular stress responses

7

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language of work or name

English

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publication date

11 October 2013

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published in

FEBS Letters

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volume

587

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issue

20

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page(s)

3303-8

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cites work

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mTOR and cancer: insights into a complex relationship

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Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

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The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

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Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90

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Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

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AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

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CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

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Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha

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Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains

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RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage

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PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis

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RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway.

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RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival

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Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA

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Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma

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In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence

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Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism

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Pontin and reptin, two related ATPases with multiple roles in cancer.

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First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay

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Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

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mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

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Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

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Insulin-like growth factor-1 protects peroxynitrite-induced cell death by preventing cytochrome c-induced caspase-3 activation

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Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation

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Epigenetic control of rDNA loci in response to intracellular energy status

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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The multifunctional nucleolus

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SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

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mTOR signaling regulates the processing of pre-rRNA in human cells

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Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing.

21 January 2018

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Pontin is localized in nucleolar fibrillar centers

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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

21 January 2018

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Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells

21 January 2018

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Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

21 January 2018

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Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

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