Scribble planar cell polarity protein (Q21116596)

PDZ superfamily

1 reference

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

26 references

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Mammalian Scribble forms a tight complex with the betaPIX exchange factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Scrib regulates PAK activity during the cell migration process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The multiple-specificity landscape of modular peptide recognition domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Defining the human deubiquitinating enzyme interaction landscape

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

guanylate kinase activity

IPI

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

ionotropic glutamate receptor binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

31 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

Mammalian Scribble forms a tight complex with the betaPIX exchange factor

HDA

cell component

postsynaptic membrane

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Mammalian Scribble forms a tight complex with the betaPIX exchange factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

myelin sheath abaxonal region

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

Scrib regulates PAK activity during the cell migration process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

Mammalian Scribble forms a tight complex with the betaPIX exchange factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

Scrib-APC-beta-catenin complex

1 reference

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

IDA

cell-cell contact zone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

ionotropic glutamate receptor complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

HDA

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

extrinsic component of postsynaptic density membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

establishment of apical/basal cell polarity

1 reference

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

synaptic vesicle targeting

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

activation of GTPase activity

1 reference

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

astrocyte cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

apoptotic process involved in morphogenesis

1 reference

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

auditory receptor cell morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

auditory receptor cell stereocilium organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

synaptic vesicle endocytosis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

protein localization to adherens junction

1 reference

9 May 2019

Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

positive regulation of apoptotic process

1 reference

9 May 2019

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

morphogenesis of embryonic epithelium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

cell population proliferation

1 reference

9 May 2019

Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

cochlear nucleus development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

negative regulation of mitotic cell cycle

1 reference

9 May 2019

Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

positive regulation of receptor recycling

IDA

1 reference

9 May 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

chemical synaptic transmission

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

establishment or maintenance of epithelial cell apical/basal polarity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

GMP metabolic process

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

GDP metabolic process

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

receptor localization to synapse

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

neurotransmitter receptor transport, endosome to postsynaptic membrane

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

neurotransmitter receptor transport postsynaptic membrane to endosome

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

suppression by virus of host type I interferon-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

suppression by virus of host innate immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

31 October 2017

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

vesicle-mediated transport in synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

regulation of postsynaptic neurotransmitter receptor internalization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

post-anal tail morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

inner ear receptor cell stereocilium organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160

1 reference

leucine-rich repeat, typical subtype

1 reference

Leucine-rich repeat

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016