Nucleophosmin 1 (Q21117747)

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mammalian protein found in Homo sapiens
  • nucleolar protein NO38
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • nucleophosmin
  • NPM1
  • nucleophosmin/nucleoplasmin family, member 1
  • Numatrin
  • testicular tissue protein Li 128
  • Nucleolar phosphoprotein B23
edit
Language Label Description Also known as
English
Nucleophosmin 1
mammalian protein found in Homo sapiens
  • nucleolar protein NO38
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • nucleophosmin
  • NPM1
  • nucleophosmin/nucleoplasmin family, member 1
  • Numatrin
  • testicular tissue protein Li 128
  • Nucleolar phosphoprotein B23

Statements

molecular function
protein binding
determination method
IPI
40 references
retrieved
8 April 2019
stated in
Detection and identification of transcription factors as interaction partners of alien in vivo
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin is essential for ribosomal protein L5 nuclear export
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Antiviral action of the tumor suppressor ARF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
retrieved
8 April 2019
stated in
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IPI
cell component
nucleolus
determination method
IDA
IEA
11 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IEA
retrieved
17 October 2017
stated in
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
Diverged nuclear localization of Werner helicase in human and mouse cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
nucleus
determination method
IDA
ISS
IEA
6 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
ISS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IEA
retrieved
17 October 2017
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
17 October 2017
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06748&geneProductId=UniProtKB:P06748
determination method
IDA
nucleolus
determination method
IBA
IDA
IEA
12 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IEA
retrieved
8 April 2019
stated in
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication
GOA
curator
UniProt
UniProt protein ID
P06748
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Diverged nuclear localization of Werner helicase in human and mouse cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06748
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
D000090243
subject named as
Nucleophosmin
0 references
 
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