Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2 (Q24317630)

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English	Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2	scientific article

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scholarly article

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13 November 2019

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2. (English)

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13 November 2019

Phosphodiesterase 4A

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GOA release 2020-03-11

2

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13 November 2019

Miles D. Houslay

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13 November 2019

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M Sullivan

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13 November 2019

F Begg

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13 November 2019

L Gordon

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13 November 2019

A S Olsen

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1 August 1998

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13 November 2019

Biochemical Journal

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13 November 2019

333 ( Pt 3)

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13 November 2019

693-703

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13 November 2019

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1 reference

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19 March 2017

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1 reference

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19 March 2017

Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene

1 reference

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19 March 2017

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

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19 March 2017

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]

1 reference

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19 March 2017

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219634

19 March 2017

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

1 reference

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19 March 2017

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs

1 reference

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19 March 2017

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1 reference

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19 March 2017

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

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19 March 2017

Multiple cyclic nucleotide phosphodiesterases

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19 March 2017

Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

1 reference

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Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region

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19 March 2017

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family

1 reference

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Signalling through SH2 and SH3 domains

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27 September 2017

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

1 reference

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27 September 2017

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

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27 September 2017

Assembly of a 1-Mb restriction-mapped cosmid contig spanning the candidate region for Finnish congenital nephrosis (NPHS1) in 19q13.1.

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27 September 2017

Signal transduction: regulation of cAMP concentration in cardiac muscle by calmodulin-dependent cyclic nucleotide phosphodiesterase

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27 September 2017

Human chromosome 19p: a fluorescence in situ hybridization map with genomic distance estimates for 79 intervals spanning 20 Mb.

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Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

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27 September 2017

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

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27 September 2017

Recent progress in understanding the hormonal regulation of phosphodiesterases.

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27 September 2017

Diversity in cyclic nucleotide phosphodiesterase isoenzyme families

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27 September 2017

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

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27 September 2017

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219634

27 September 2017

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites

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27 September 2017

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

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27 September 2017

The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

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30 May 2018

Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

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30 May 2018

Tailoring cAMP-signalling responses through isoform multiplicity

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30 May 2018

Characterization of an intronic promoter of a cyclic adenosine 3',5'-monophosphate (cAMP)-specific phosphodiesterase gene that confers hormone and cAMP inducibility.

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30 May 2018

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

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30 May 2018

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1 reference

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30 May 2018

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma

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30 May 2018

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

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30 May 2018

An integrated metric physical map of human chromosome 19.

1 reference

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30 May 2018

Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

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30 May 2018

A 30-Mb metric fluorescence in situ hybridization map of human chromosome 19q.

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29 November 2018

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

1 reference

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29 November 2018

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

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29 November 2018

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10.1042/BJ3330693

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13 November 2019

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13 November 2019

1 reference

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13 November 2019

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