Ring finger protein 168 (Q21127053)

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mammalian protein found in Homo sapiens

RNF168
ring finger protein 168, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase RNF168
RING-type E3 ubiquitin transferase RNF168
RING finger protein 168

Language	Label	Description	Also known as
English	Ring finger protein 168	mammalian protein found in Homo sapiens	RNF168 ring finger protein 168, E3 ubiquitin protein ligase E3 ubiquitin-protein ligase RNF168 RING-type E3 ubiquitin transferase RNF168 RING finger protein 168

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

E3 ubiquitin-protein ligase RNF168

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IYW5

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IYW5

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

chromatin binding

determination method

3 references

27 March 2018

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

K63-linked polyubiquitin modification-dependent protein binding

determination method

3 references

8 April 2019

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

ubiquitin binding

determination method

protein binding

determination method

4 references

8 April 2019

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

nucleosome binding

determination method

1 reference

8 April 2019

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

ubiquitin-protein transferase activity

determination method

8 references

8 April 2019

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

histone binding

determination method

3 references

27 March 2018

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

chromatin binding

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

histone binding

determination method

4 references

8 April 2019

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

ubiquitin binding

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

site of double-strand break

determination method

ubiquitin ligase complex

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

protein-containing complex

determination method

1 reference

8 April 2019

The histone demethylase LSD1/KDM1A promotes the DNA damage response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

ubiquitin ligase complex

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

biological process

response to ionizing radiation

determination method

interstrand cross-link repair

determination method

1 reference

8 April 2019

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

histone H2A-K13 ubiquitination

determination method

1 reference

8 April 2019

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

protein K63-linked ubiquitination

determination method

1 reference

8 April 2019

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

histone H2A K63-linked ubiquitination

determination method

4 references

8 April 2019

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

negative regulation of transcription elongation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

cellular response to DNA damage stimulus

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

protein ubiquitination

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

isotype switching

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

double-strand break repair via nonhomologous end joining

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

double-strand break repair

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

positive regulation of DNA repair

determination method

3 references

27 March 2018

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

27 March 2018

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IYW5&geneProductId=UniProtKB:Q8IYW5

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

response to ionizing radiation

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

histone H2A ubiquitination

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

positive regulation of DNA repair

determination method

4 references

8 April 2019

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

8 April 2019

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IYW5

determination method

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IYW5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000320898

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000320898

ENSP00000396712

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396712

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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