The E3 ligase RNF8 regulates KU80 removal and NHEJ repair (Q24302499)

Ring finger protein 168

1 reference

Ring finger protein 8

1 reference

X-ray repair cross complementing 5

1 reference

protein K63-linked ubiquitination

1 reference

Ring finger protein 8

1 reference

Nature Structural & Molecular Biology

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Lin Feng

1

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Junjie Chen

series ordinal

2

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language of work or name

English

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publication date

February 2012

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published in

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volume

19

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issue

2

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page(s)

201-6

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cites work

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

1 reference

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

19 March 2017

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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

19 March 2017

1 reference

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

19 March 2017

1 reference

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MERIT40 facilitates BRCA1 localization and DNA damage repair

19 March 2017

1 reference

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MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

19 March 2017

1 reference

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

19 March 2017

1 reference

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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

19 March 2017

1 reference

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Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

19 March 2017

1 reference

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Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

19 March 2017

1 reference

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The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

19 March 2017

1 reference

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

19 March 2017

1 reference

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

19 March 2017

1 reference

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

19 March 2017

1 reference

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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Themes and variations on ubiquitylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

A role for ubiquitin in selective autophagy

7 April 2017

1 reference

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Ku80 removal from DNA through double strand break-induced ubiquitylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888515

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2211

Ubiquitin signalling in DNA replication and repair

21 January 2018

2 references

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2211

31 March 2020

https://pubmed.ncbi.nlm.nih.gov/22266820

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2211

31 March 2020

Identifiers

DOI

10.1038/NSMB.2211

1 reference

Dimensions Publication ID

1035810

1045057423

0 references

Fatcat ID

release_knqeg7ull5fdhomnhg6wkriuve

0 references

1035810

1 reference

1 reference

1 reference