RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins (Q24309287)

histone H2A K63-linked ubiquitination

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Daniel Durocher

9

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Stephanie Panier

8

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Jan Ellenberg

7

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Jiří Bártek

10

Jiri Bartek

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Jiří Lukáš

11

Jiri Lukas

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Dorthe H Larsen

Dorthe Helena Larsen

5

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Claudia Lukas

Claudia Lukas

12

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Simon Bekker-Jensen

Simon Bekker-Jensen

3

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Rainer Pepperkok

Rainer Pepperkok

6

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author name string

Carsten Doil

1

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Niels Mailand

2

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Patrice Menard

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

4

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language of work or name

English

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publication date

6 February 2009

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published in

Cell

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volume

136

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issue

3

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page(s)

435-46

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cites work

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

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H2AX: the histone guardian of the genome

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