telomeric repeat binding factor 1 (Q21130708)

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mammalian protein found in Homo sapiens
  • NIMA-interacting protein 2
  • telomeric repeat-binding factor 1
  • TTAGGG repeat-binding factor 1
  • TERF1
  • telomeric repeat binding factor (NIMA-interacting) 1
  • telomeric protein Pin2/TRF1
  • Telomeric Repeat Binding Protein 1
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Language Label Description Also known as
English
telomeric repeat binding factor 1
mammalian protein found in Homo sapiens
  • NIMA-interacting protein 2
  • telomeric repeat-binding factor 1
  • TTAGGG repeat-binding factor 1
  • TERF1
  • telomeric repeat binding factor (NIMA-interacting) 1
  • telomeric protein Pin2/TRF1
  • Telomeric Repeat Binding Protein 1

Statements

molecular function
telomeric DNA binding
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IEA
retrieved
8 April 2019
stated in
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
retrieved
8 April 2019
stated in
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
retrieved
8 April 2019
stated in
Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
retrieved
8 April 2019
stated in
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
retrieved
8 April 2019
stated in
GNL3L stabilizes the TRF1 complex and promotes mitotic transition
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
protein binding
determination method
IPI
35 references
retrieved
8 April 2019
stated in
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of selective ubiquitination of TRF1 by SCFFbx4
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
POT1 as a terminal transducer of TRF1 telomere length control
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase-1 assembly to large protein complexes blocks its telomeric function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Protein requirements for sister telomere association in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
GNL3L stabilizes the TRF1 complex and promotes mitotic transition
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
PTOP interacts with POT1 and regulates its localization to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
retrieved
8 April 2019
stated in
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IPI
cell component
nucleus
determination method
NAS
IDA
IEA
6 references
retrieved
8 April 2019
stated in
A human telomeric protein
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IEA
retrieved
8 April 2019
stated in
Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors
GOA
curator
UniProt
UniProt protein ID
P54274
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
retrieved
8 April 2019
stated in
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54274
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
D035321
subject named as
Telomeric Repeat Binding Protein 1
0 references
 
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