Polypyrimidine tract binding protein 1 (Q21133777)

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mammalian protein found in Homo sapiens

polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
PTBP1
57 kDa RNA-binding protein PPTB-1
heterogeneous nuclear ribonucleoprotein I
heterogeneous nuclear ribonucleoprotein polypeptide I
RNA-binding protein
hnRNP I
polypyrimidine tract-binding protein 1

Language	Label	Description	Also known as
English	Polypyrimidine tract binding protein 1	mammalian protein found in Homo sapiens	polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) PTBP1 57 kDa RNA-binding protein PPTB-1 heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein polypeptide I RNA-binding protein hnRNP I polypyrimidine tract-binding protein 1

Statements

1 reference

13 November 2019

UniProt protein ID

RNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

Nucleotide-binding alpha-beta plait domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

PTBP1, RNA recognition motif 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTBP1, RNA recognition motif 3, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTBP1, RNA recognition motif 2-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

RNA recognition motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

pre-mRNA binding

determination method

1 reference

8 April 2019

Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

protein binding

determination method

9 references

8 April 2019

Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

A physical interaction network of dengue virus and human proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

poly-pyrimidine tract binding

determination method

1 reference

8 April 2019

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

determination method

5 references

26 September 2017

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

determination method

5 references

8 April 2019

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

determination method

1 reference

8 April 2019

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

extracellular exosome

determination method

1 reference

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26599&geneProductId=UniProtKB:P26599

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

biological process

mRNA splicing, via spliceosome

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

mRNA processing

determination method

3 references

8 April 2019

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

negative regulation of mRNA splicing, via spliceosome

determination method

1 reference

8 April 2019

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

regulation of alternative mRNA splicing, via spliceosome

determination method

negative regulation of RNA splicing

determination method

1 reference

8 April 2019

Expression of human nPTB is limited by extreme suboptimal codon content

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

negative regulation of muscle cell differentiation

determination method

1 reference

8 April 2019

RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

fibroblast growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

IRES-dependent viral translational initiation

determination method

1 reference

8 April 2019

Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

RNA metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

positive regulation of protein dephosphorylation

determination method

1 reference

8 April 2019

MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

positive regulation of calcineurin-NFAT signaling cascade

determination method

1 reference

8 April 2019

MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26599

determination method

RNA recognition motif domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

PTBP1, RNA recognition motif 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

PTBP1, RNA recognition motif 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

PTBP1, RNA recognition motif 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26599

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000014112

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000014112

ENSP00000349428

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349428

ENSP00000408096

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408096

ENSP00000342332

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342332

ENSP00000465451

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465451

ENSP00000465652

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465652

ENSP00000465825

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465825

ENSP00000466250

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466250

ENSP00000468565

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468565

ENSP00000478097

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478097

ENSP00000478414

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478414

ENSP00000478974

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478974

ENSP00000486218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486218

ENSP00000489604

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489604

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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